Morrow Sarah A, Rosehart Heather, Pantazopoulos Koula
From the Dept. of Clinical Neurological Sciences, Western University, London Health Sciences Center, London, Ontario, Canada (SAM); the Dept. of Clinical Neurological Sciences, London Health Sciences Center, London, Ontario, Canada (HR); and Parkwood Institute, London, Ontario, Canada (KP).
J Neuropsychiatry Clin Neurosci. 2016 Spring;28(2):118-23. doi: 10.1176/appi.neuropsych.15070167. Epub 2015 Nov 16.
Cognitive impairment, anxiety, and depressive symptoms are common in multiple sclerosis (MS) and are known to interact in non-MS populations. This retrospective chart review examined this relationship in a relapsing-remitting MS population. A significant difference on measures of processing speed/working memory and visual-spatial memory was found in MS patients with anxiety compared with nonanxious MS patients, while a significant difference was found on measures of processing speed, visual-spatial memory and executive function in MS patients with depressive symptoms compared with those without. Further research is needed to determine the causal relationship between anxiety and depressive symptoms and cognitive impairment.
认知障碍、焦虑和抑郁症状在多发性硬化症（MS）中很常见，并且已知在非MS人群中会相互作用。这项回顾性图表审查研究了复发缓解型MS人群中的这种关系。与无焦虑的MS患者相比，有焦虑的MS患者在处理速度/工作记忆和视觉空间记忆测量方面存在显著差异，而与无抑郁症状的MS患者相比，有抑郁症状的MS患者在处理速度、视觉空间记忆和执行功能测量方面存在显著差异。需要进一步研究以确定焦虑和抑郁症状与认知障碍之间的因果关系。
