Harris John E
Department of Medicine, Division of Dermatology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
J Invest Dermatol. 2015 Dec;135(12):2921-2923. doi: 10.1038/jid.2015.372.
Melanocytes in patients with vitiligo possess intrinsic abnormalities that contribute to its pathogenesis. Regazzetti et al. report that CXCL10 expression reflects subtle inflammation in normal-appearing skin but not in stable depigmented lesions, supporting the hypothesis that melanocytes themselves initiate autoimmune inflammation prior to clinically evident disease. In addition, they find that oxidative stress in melanocytes impairs WNT signaling and that targeting this pathway induces melanoblast differentiation. Thus, activating the WNT pathway may serve as an adjunctive strategy to support repigmentation in patients with vitiligo.
白癜风患者的黑素细胞存在内在异常，这与其发病机制有关。雷加泽蒂等人报告称，CXCL10的表达反映了外观正常皮肤中的轻微炎症，但在稳定的色素脱失性皮损中则不然，这支持了黑素细胞自身在临床明显疾病出现之前引发自身免疫炎症的假说。此外，他们发现黑素细胞中的氧化应激会损害WNT信号通路，而靶向该通路可诱导黑素母细胞分化。因此，激活WNT通路可能作为一种辅助策略，以支持白癜风患者的色素再生。
