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孕妇、哺乳期妇女及儿童维生素D缺乏的预防与后果:一场将维生素D提上全球议程优先位置的研讨会

Prevention and consequences of vitamin D deficiency in pregnant and lactating women and children: A symposium to prioritise vitamin D on the global agenda.

作者信息

Schoenmakers Inez, Pettifor John M, Peña-Rosas Juan-Pablo, Lamberg-Allardt Christel, Shaw Nick, Jones Kerry S, Lips Paul, Glorieux Francis H, Bouillon Roger

机构信息

Medical Research Council (MRC) Human Nutrition Research, UK.

MRC/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

J Steroid Biochem Mol Biol. 2016 Nov;164:156-160. doi: 10.1016/j.jsbmb.2015.11.004. Epub 2015 Nov 10.

Abstract

The Department of Nutrition for Health and Development of the World Health Organization (WHO) in collaboration with the Executive Committee of the 18th Vitamin D Workshop (VDW), organised a joint symposium on the prevention and consequences of vitamin D deficiency in pregnant women and children, convening experts on vitamin D, clinicians and policy-makers. The overall aim was to identify priority areas for research and to discuss the need for global options for policy, with a focus on the prevention of rickets in infants and children and vitamin D deficiency in pregnant women. The scope and purpose were: (i) to present the WHO research strategy for health, addressing vitamin D-related public health problems and the process for the development of evidence-informed guidelines in general and how vitamin D interventions in diverse populations could be prioritised; (ii) to provide an overview of vitamin D status in children and pregnant and lactating women across the world; (iii) to review the health risks associated with vitamin D deficiency in children and in pregnant women and their offspring; (iv) to understand the aetiology of vitamin D deficiency in pregnant women and children; (v) to identify and interpret biomarkers to assess vitamin D status and to consider possible clinical and biochemical screening tools for determining the prevalence of nutritional rickets in at risk groups or communities; and (vi) to provide an overview of policies and recommendations on vitamin D across the world. The format of the symposium was a composite of comprehensive scientific presentations and a panel debate with international experts on WHO guidelines, nutritional rickets, nutritional policy and consequences of vitamin D deficiency during pregnancy. This paper summarizes the content and outcomes of the panel debate.

摘要

世界卫生组织(WHO)健康与发展营养司与第18届维生素D研讨会(VDW)执行委员会合作,组织了一次关于孕妇和儿童维生素D缺乏症的预防及后果的联合研讨会,召集了维生素D领域的专家、临床医生和政策制定者。总体目标是确定研究的优先领域,并讨论全球政策选择的必要性,重点是预防婴幼儿佝偻病和孕妇维生素D缺乏症。研讨会的范围和目的包括:(i)介绍WHO的健康研究战略,阐述与维生素D相关的公共卫生问题以及制定循证指南的总体过程,以及如何确定不同人群中维生素D干预措施的优先级;(ii)概述全球儿童、孕妇和哺乳期妇女的维生素D状况;(iii)审查儿童、孕妇及其后代维生素D缺乏症相关的健康风险;(iv)了解孕妇和儿童维生素D缺乏症的病因;(v)识别和解读评估维生素D状况的生物标志物,并考虑可能用于确定高危群体或社区营养性佝偻病患病率的临床和生化筛查工具;(vi)概述全球有关维生素D的政策和建议。研讨会的形式包括全面的科学报告以及与国际专家就WHO指南、营养性佝偻病、营养政策以及孕期维生素D缺乏症的后果进行的小组辩论。本文总结了小组辩论的内容和成果。

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