Kanoe M, Yamanaka M
Department of Veterinary Microbiology, Faculty of Agriculture, Yamaguchi University, Japan.
J Med Microbiol. 1989 May;29(1):13-7. doi: 10.1099/00222615-29-1-13.
Fusobacterium necrophorum aggregated bovine platelets. The aggregation was paralleled by the haemagglutinating ability of the organism. Treatment of the bacterial cells with antiserum to the homologous purified haemagglutinin reduced the degree of platelet aggregation. Scanning electronmicroscopy revealed that little lysis of the affected platelets occurred during the 1-h incubation period. Purified haemagglutinin became bound to the surfaces of the platelet cells as shown by immunofluorescence microscopy. These observations suggest that platelet aggregation is mediated by the haemagglutinin and may be related to the pathogenicity of the bacterium.
坏死梭杆菌可凝集牛血小板。这种凝集作用与该菌的血凝能力平行。用针对同源纯化血凝素的抗血清处理细菌细胞可降低血小板凝集程度。扫描电子显微镜显示，在1小时的孵育期内，受影响的血小板几乎没有发生裂解。免疫荧光显微镜显示，纯化的血凝素可结合到血小板细胞表面。这些观察结果表明，血小板凝集是由血凝素介导的，可能与该细菌的致病性有关。
