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运用感知映射方法来了解城市少数族裔HIV阳性患者在参与临床研究时所感知到的障碍和益处方面的性别差异。

Using perceptual mapping methods to understand gender differences in perceived barriers and benefits of clinical research participation in urban minority HIV+ patients.

作者信息

Bass Sarah Bauerle, Wolak Caitlin, Greener Judith, Tedaldi Ellen, Nanavati Aasit, Ruppert Katey, Gordon Thomas F

机构信息

a Department of Social and Behavioral Sciences, Temple University College of Public Health , Temple University , Philadelphia , PA , USA.

b Department of Medicine , Temple University Hospital , Philadelphia , PA , USA.

出版信息

AIDS Care. 2016;28(4):528-36. doi: 10.1080/09540121.2015.1112352. Epub 2015 Nov 17.

Abstract

Minority participation in HIV clinical trials research is critical to understanding the impact of medications or behavioral interventions, but little is known about gender differences in perceptions of participation. We surveyed 50 minority HIV+ patients from an urban clinic to assess perceived risks/benefits of clinical trial research participation and used innovative marketing methods to analyze results. Perceptual mapping and vector message-modeling, a method that creates 3-D models representing how groups conceptualize elements, were used to assess how male and female participants could be motivated to participate. Results showed men farther away from participation and more concerned with HIV disclosure and experimentation than women. Men expressed distrust of the medical system, doubted HIV's origin, and knew less about research implementation. Women were closer to participation in both behavior and medical trials and perceived medication issues as more significant, including fear of losing medication stability, medications not working, being in the placebo group, and experiencing side effects. Vector modeling shows that messages would need to focus on different aspects of clinical research for men and women and that interventions aimed at minority HIV+ patients to encourage clinical trial participation would need to be targeted to their unique perceptions. Understanding gender perceptions of HIV clinical research has significant implications for targeting messages to increase minority participation.

摘要

少数群体参与艾滋病临床试验研究对于了解药物或行为干预的影响至关重要,但对于参与认知中的性别差异却知之甚少。我们对一家城市诊所的50名少数群体艾滋病病毒阳性患者进行了调查,以评估参与临床试验研究的感知风险/益处,并使用创新的营销方法来分析结果。感知映射和矢量信息建模是一种创建代表群体如何概念化元素的三维模型的方法,用于评估如何激励男性和女性参与者参与。结果显示,与女性相比,男性离参与更远,更关注艾滋病病毒的披露和试验。男性表达了对医疗系统的不信任,怀疑艾滋病病毒的起源,对研究实施了解较少。女性在行为和医学试验中都更接近参与,并且认为药物问题更为重要,包括担心失去药物稳定性、药物无效、处于安慰剂组以及出现副作用。矢量建模表明,信息需要针对男性和女性关注临床研究的不同方面,并且针对少数群体艾滋病病毒阳性患者鼓励参与临床试验的干预措施需要针对他们的独特认知。了解艾滋病临床研究中的性别认知对于针对性地传达信息以增加少数群体参与具有重要意义。

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