Fromme Petra
School of Molecular Sciences, Arizona State University, Tempe, Arizona, USA and at the Center for Applied Structural Discovery, Biodesign Institute, Arizona State University, Tempe, Arizona, USA.
Nat Chem Biol. 2015 Dec;11(12):895-9. doi: 10.1038/nchembio.1968.
X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method’s great potential to make new structural discoveries, such as the ability to generate molecular movies of biomolecules at work.
X射线晶体学作为结构生物学的主要手段，已因使用X射线自由电子激光的飞秒串联晶体学的出现而发生了变革。本文将探讨其快速发展历程与发现成果，以及当前面临的挑战，还有该方法在做出新的结构发现方面的巨大潜力，比如能够生成生物分子工作时的分子动态影像。
