Ramakrishnan Vijay R, Hauser Leah J, Frank Daniel N
aDepartment of Otolaryngology, University of Colorado School of Medicine bDivision of Infectious Diseases cUniversity of Colorado Microbiome Research Consortium, Aurora, Colorado, USA.
Curr Opin Otolaryngol Head Neck Surg. 2016 Feb;24(1):20-5. doi: 10.1097/MOO.0000000000000221.
The development of culture-independent bacterial DNA sequencing techniques and integration into research practice has led to a burgeoning interest in the microbiome and its relevance to human health and disease. Introduction into the study of chronic rhinosinusitis in the past few years has shaped current thinking on the role of bacteria in the disease process.
Rich and diverse populations of bacteria inhabit the sinonasal cavity at all times. Decreased bacterial richness and diversity may be associated with disease state and outcomes.
Although there is much to be explored, the sinus microbiome appears to have potentially promising roles in many aspects of sinus health and disease.
不依赖培养的细菌DNA测序技术的发展及其在研究实践中的应用，引发了人们对微生物组及其与人类健康和疾病相关性的浓厚兴趣。在过去几年中，该技术引入慢性鼻窦炎研究，影响了当前对细菌在疾病过程中作用的认识。
鼻窦腔中始终存在丰富多样的细菌群落。细菌丰富度和多样性的降低可能与疾病状态及预后相关。
尽管仍有许多有待探索之处，但鼻窦微生物组在鼻窦健康和疾病的诸多方面似乎具有潜在的重要作用。
