Sá Jamile, Mariano Lorena C, Canguçu Daiane, Coutinho Thaynara S L, Hoshi Ryuichi, Medrado Alena Peixoto, Martelli-Junior Hercílio, Coletta Ricardo D, Reis Silvia R A
Cleft Palate Craniofac J. 2016 Nov;53(6):714-719. doi: 10.1597/14-303. Epub 2015 Nov 17.
The aim of this study was to radiographically investigate the prevalence of dental anomalies outside the cleft area in a group of Brazilian patients with nonsyndromic cleft lip and/or palate (NSCL/P).
DESIGN, PARTICIPANTS, AND SETTING: A retrospective analysis of 207 panoramic radiographs of patients with NSCL/P aged 12 to 45 years without history of tooth extraction and orthodontic treatment was performed.
Dental anomalies were found in 75.4% of the patients, and tooth agenesis (29.2%) and supernumerary tooth (2.6%) were the most common anomalies. The risk of agenesis was higher among the individuals with cleft palate (CP) compared with individuals with cleft lip (CL) and cleft lip and palate (CLP) (agenesis: CP versus CL: odds ratio 6.27, 95% confidence interval 2.21-17.8, P = .0003; CP versus CLP: odds ratio 2.94; 95% confidence interval 1.27-6.81, P = .01). The frequency of dental agenesis was higher in patients with unilateral complete CLP (agenesis: P < .0001), incomplete bilateral CLP (agenesis: P = .0013), complete CP (agenesis: P < .0001), and incomplete CP (agenesis: P < .0001). The frequency of supernumerary teeth was higher in patients with bilateral complete CLP (P < .0001). The frequency of dental agenesis (P < .0001) and ectopic tooth (P = .009) was higher than the frequency estimated for general population.
The prevalence of dental anomalies in patients with NSCL/P was higher than that reported in overall population. This study found preferential associations between dental anomalies and specific extensions of NSCL/P, suggesting that dental agenesis and ectopic tooth may be part of oral cleft subphenotypes.
本研究旨在通过影像学检查，调查一组巴西非综合征性唇腭裂（NSCL/P）患者腭裂区域以外牙齿异常的患病率。
设计、参与者与研究环境：对207例年龄在12至45岁之间、无拔牙及正畸治疗史的NSCL/P患者的全景X线片进行回顾性分析。
75.4%的患者存在牙齿异常，其中最常见的异常为牙齿缺失（29.2%）和多生牙（2.6%）。与唇裂（CL）和唇腭裂（CLP）患者相比，腭裂（CP）患者牙齿缺失的风险更高（牙齿缺失：CP与CL相比：比值比6.27，95%置信区间2.21 - 17.8，P = 0.0003；CP与CLP相比：比值比2.94；95%置信区间1.27 - 6.81，P = 0.01）。单侧完全性CLP患者（牙齿缺失：P < 0.0001）、不完全双侧CLP患者（牙齿缺失：P = 0.0013）、完全性CP患者（牙齿缺失：P < 0.0001）和不完全性CP患者（牙齿缺失：P < 0.0001）牙齿缺失的频率更高。双侧完全性CLP患者多生牙的频率更高（P < 0.0001）。牙齿缺失（P < 0.0001）和异位牙（P = 0.009）的频率高于一般人群的估计频率。
NSCL/P患者牙齿异常的患病率高于总体人群报告的患病率。本研究发现牙齿异常与NSCL/P的特定类型之间存在优先关联，提示牙齿缺失和异位牙可能是口腔腭裂亚表型的一部分。
