循环miR-21-5p和miR-148a-3p作为胸腺上皮肿瘤中新兴的非侵入性生物标志物。
Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors.
作者信息
Bellissimo Teresa, Russo Emanuele, Ganci Federica, Vico Carmen, Sacconi Andrea, Longo Flavia, Vitolo Domenico, Anile Marco, Disio Daniele, Marino Mirella, Blandino Giovanni, Venuta Federico, Fazi Francesco
机构信息
a Department of Anatomical, Histological , Forensic and orthopedic Sciences, Section of Histology & Medical Embryology, Sapienza University of Rome , Rome , Italy.
b Department of Thoracic Surgery , Azienda Policlinico Umberto I, Sapienza University of Rome, Rome, Italy and Fondazione Eleonora Lorillard Spencer Cenci.
出版信息
Cancer Biol Ther. 2016;17(1):79-82. doi: 10.1080/15384047.2015.1108493.
Thymic epithelial cells give rise to both thymoma and thymic carcinoma. A crucial advance in thymic epithelial tumors (TET) management may derive from the identification of novel molecular biomarkers able to improve diagnosis, prognosis and treatment planning.In a previous study, we identified microRNAs that were differentially expressed in tumor vs normal thymic tissues. Among the microRNAs resulted up-regulated in TET tissues, we evaluated miR-21-5p, miR-148a-3p, miR-141-3p, miR-34b-5p, miR-34c-5p, miR-455-5p as blood plasma circulating non-invasive biomarkers for TET management.We firstly report that the expression levels of specific onco-miRNAs, that we found upregulated in the blood plasma collected from TET patients at surgery, resulted significantly reduced in follow-up samples.This pilot study suggests that circulating miR-21-5p and miR-148a-3p could represent novel non-invasive biomarkers to evaluate the efficacy of therapy and the prognosis of TET.
胸腺上皮细胞可引发胸腺瘤和胸腺癌。胸腺上皮肿瘤（TET）管理方面的一项关键进展可能源于新型分子生物标志物的识别，这些标志物能够改善诊断、预后和治疗规划。在先前的一项研究中，我们鉴定出了在肿瘤组织与正常胸腺组织中差异表达的微小RNA。在TET组织中上调的微小RNA中，我们评估了miR-21-5p、miR-148a-3p、miR-141-3p、miR-34b-5p、miR-34c-5p、miR-455-5p作为TET管理的血浆循环非侵入性生物标志物。我们首次报告，我们发现手术时从TET患者采集的血浆中上调的特定癌基因微小RNA的表达水平在随访样本中显著降低。这项初步研究表明，循环miR-21-5p和miR-148a-3p可能代表评估TET治疗效果和预后的新型非侵入性生物标志物。
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