儿童莱姆病性神经伯氏疏螺旋体病中的性别差异
Gender Differences in Childhood Lyme Neuroborreliosis.
作者信息
Tveitnes Dag, Øymar Knut
机构信息
Department of Pediatrics, Stavanger University Hospital, Gerd Ragna Bloch Thorsens Gate 8, 4011 Stavanger, Norway.
Department of Pediatrics, Stavanger University Hospital, Gerd Ragna Bloch Thorsens Gate 8, 4011 Stavanger, Norway ; Department of Clinical Science, University of Bergen, 5020 Bergen, Norway.
出版信息
Behav Neurol. 2015;2015:790762. doi: 10.1155/2015/790762. Epub 2015 Oct 20.
BACKGROUND
Many neurological diseases show differences between genders. We studied gender differences in childhood Lyme neuroborreliosis (LNB) in an endemic area of Lyme borreliosis in Norway.
METHODS
In a population based study, all children (<14 years of age) with symptoms suspicious of LNB, including all children with acute facial nerve palsy, were evaluated for LNB by medical history, clinical examination, blood tests, and lumbar puncture. LNB was diagnosed according to international criteria.
RESULTS
142 children were diagnosed with LNB during 2001-2009. Facial nerve palsy was more common in girls (86%) than in boys (62%) (p < 0.001), but headache and/or neck stiffness as the only symptom was more common in boys (30%) than in girls (10%) (p = 0.003). The girls were younger than boys and had a shorter duration of symptoms, but boys had a higher level of pleocytosis than girls. In a multivariate analysis, both gender and having headache and neck stiffness were associated with a higher level of pleocytosis.
CONCLUSION
Girls and boys have different clinical presentations of LNB, and boys have a higher level of inflammation than girls independent of the clinical presentation.
背景
许多神经系统疾病存在性别差异。我们在挪威莱姆病的一个流行地区研究了儿童莱姆神经疏螺旋体病（LNB）的性别差异。
方法
在一项基于人群的研究中，对所有有LNB可疑症状的儿童（<14岁），包括所有急性面神经麻痹儿童，通过病史、临床检查、血液检查和腰椎穿刺进行LNB评估。LNB根据国际标准进行诊断。
结果
2001年至2009年期间，142名儿童被诊断为LNB。面神经麻痹在女孩中（86%）比在男孩中（62%）更常见（p<0.001），但仅以头痛和/或颈部僵硬为唯一症状的情况在男孩中（30%）比在女孩中（10%）更常见（p = 0.003）。女孩比男孩年龄小，症状持续时间短，但男孩的脑脊液细胞增多水平比女孩高。在多变量分析中，性别以及头痛和颈部僵硬都与较高的脑脊液细胞增多水平相关。
结论
女孩和男孩的LNB临床表现不同，且男孩的炎症水平高于女孩，与临床表现无关。
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