Colli Andrea, Carrozzini Massimiliano, Galuppo Marco, Comisso Marina, Toto Francesca, Gregori Dario, Gerosa Gino
Cardiac Surgery Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Biostatistics, Epidemiology and Public Health Unit, Department of Cardiac, Thoracic and Vascular Sciences, University of Padua, Padua, Italy.
Heart Vessels. 2016 Oct;31(10):1616-24. doi: 10.1007/s00380-015-0770-1. Epub 2015 Nov 17.
To evaluate predictors of early and long-term outcomes of surgical repair of acute Type A aortic dissection. Retrospective single-centre study evaluating patients surgically treated between 1998 and 2013. Clinical follow-up was performed. Complications were classified according to the International Aortic Arch Surgery Study Group recommendations. Statistical analysis included univariate and multivariate analysis of preoperative and operative data. One hundred eighty-five patients were evaluated. The follow-up was complete for 180 patients (97 %). Mean age was 63 years, 82 % had a DeBakey type I aortic dissection, 18 % a type II. Eleven patients (6 %) died intraoperatively, 119 of the remaining (68 %) had postoperative complications. Thirty-day mortality was 21 % (38 patients). Average ICU and hospital stay were 6 and 14 days, respectively. During a mean follow-up time of 6 ± 4 years we observed 44 deaths (31 %). Twenty patients (14 %) needed late thoracic aorta reoperation. Results from the multivariate analysis are as follows. Thirty-day mortality was associated with abdominal pain at presentation (p < 0.01). The incidence of postoperative complications was related to older age at intervention (p < 0.01) and longer cross-clamp time (p < 0.01). Mortality at follow-up was significantly increased by older age at intervention (p < 0.01), with a logarithmic growth after 60 years, female sex (p < 0.01), preoperative limb ischemia (p = 0.02) and DHCA (p < 0.01). The surgical results of type A aortic dissection are affected by age at intervention with a logarithmic increase of late mortality in patients older than 60 years.
评估急性A型主动脉夹层手术修复的早期和长期预后的预测因素。对1998年至2013年间接受手术治疗的患者进行回顾性单中心研究。进行了临床随访。并发症根据国际主动脉弓外科研究组的建议进行分类。统计分析包括对术前和手术数据的单变量和多变量分析。共评估了185例患者。180例患者(97%)完成了随访。平均年龄为63岁,82%为DeBakey I型主动脉夹层,18%为II型。11例患者(6%)术中死亡,其余119例(68%)有术后并发症。30天死亡率为21%(38例患者)。平均重症监护病房(ICU)和住院时间分别为6天和14天。在平均6±4年的随访期内,我们观察到44例死亡(31%)。20例患者(14%)需要后期胸主动脉再次手术。多变量分析结果如下。30天死亡率与就诊时腹痛相关(p<0.01)。术后并发症的发生率与干预时年龄较大(p<0.01)和主动脉阻断时间较长(p<0.01)有关。随访时的死亡率因干预时年龄较大(p<0.01)、60岁后呈对数增长、女性性别(p<0.01)、术前肢体缺血(p=0.02)和深低温停循环(p<0.01)而显著增加。A型主动脉夹层的手术结果受干预时年龄的影响,60岁以上患者的晚期死亡率呈对数增加。