脂肪因子、糖尿病与动脉粥样硬化：一种炎症关联
Adipokines, diabetes and atherosclerosis: an inflammatory association.
作者信息
Freitas Lima Leandro C, Braga Valdir de Andrade, do Socorro de França Silva Maria, Cruz Josiane de Campos, Sousa Santos Sérgio H, de Oliveira Monteiro Matheus M, Balarini Camille de Moura
机构信息
Biological Sciences Institute, Federal University of Minas Gerais Belo Horizonte, Brazil.
Biotechnology Center, Federal University of Paraiba (Universidade Federal da Paraíba) Joao Pessoa, Brazil.
出版信息
Front Physiol. 2015 Nov 3;6:304. doi: 10.3389/fphys.2015.00304. eCollection 2015.
Abstract
Cardiovascular diseases can be considered the most important cause of death in diabetic population and diabetes can in turn increase the risk of cardiovascular events. Inflammation process is currently recognized as responsible for the development and maintenance of diverse chronic diseases, including diabetes and atherosclerosis. Considering that adipose tissue is an important source of adipokines, which may present anti and proinflammatory effects, the aim of this review is to explore the role of the main adipokines in the pathophysiology of diabetes and atherosclerosis, highlighting the therapeutic options that could arise from the manipulation of these signaling pathways both in humans and in translational models.
摘要
心血管疾病可被视为糖尿病患者最重要的死因，而糖尿病反过来又会增加心血管事件的风险。炎症过程目前被认为是包括糖尿病和动脉粥样硬化在内的多种慢性疾病发生和维持的原因。鉴于脂肪组织是脂肪因子的重要来源，脂肪因子可能具有抗炎和促炎作用，本综述的目的是探讨主要脂肪因子在糖尿病和动脉粥样硬化病理生理学中的作用，强调通过操纵这些信号通路在人类和转化模型中可能产生的治疗选择。
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