Zheng Yueqin, Ji Xingyue, Ji Kaili, Wang Binghe
Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, GA 30303, USA.
Acta Pharm Sin B. 2015 Sep;5(5):367-77. doi: 10.1016/j.apsb.2015.06.004. Epub 2015 Aug 21.
Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, their chemical properties, and some of their potential therapeutic applications.
硫化氢（H₂S）与一氧化氮（NO）和一氧化碳（CO）一起被公认为三种气体信号分子之一。作为一种信号分子，H₂S在生理学中发挥着重要作用，并在药物应用中显示出巨大潜力。因此，出于各种原因，需要开发H₂S前药。在这篇综述中，我们总结了不同的H₂S前药、它们的化学性质以及一些潜在的治疗应用。
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