Park Chung-Min, Zhao Yu, Zhu Zhaohui, Pacheco Armando, Peng Bo, Devarie-Baez Nelmi O, Bagdon Powell, Zhang Hui, Xian Ming
Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
Mol Biosyst. 2013 Oct;9(10):2430-4. doi: 10.1039/c3mb70145j.
A series of O-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mouse melanoma cells.
设计并合成了一系列 O-芳基和烷基取代的二硫代磷酸酯作为硫化氢（H₂S）供体。使用荧光方法评估了这些化合物的 H₂S 释放能力。O-芳基取代的供体显示出缓慢且持续的 H₂S 释放，而 O-烷基化化合物显示出非常弱的 H₂S 释放能力。我们还评估了供体对过氧化氢（H₂O₂）诱导的心肌细胞氧化损伤的保护作用以及供体对 B16BL6 小鼠黑色素瘤细胞的毒性。
