Huggins Alison B, Garg Sunir J, Sando Ralph S
*MidAtlantic Retina, The Retina Service of Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania; and †Accuvision Eye M.D. Caregroup, The Cataract and Primary Eye Care Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Retin Cases Brief Rep. 2015 Nov 13. doi: 10.1097/ICB.0000000000000247.
To investigate and identify hereditary spherocytosis as a possible risk factor for the development of a central retinal vein occlusion in a young, otherwise healthy, adult.
This study is a retrospective case description of a single female patient.
A 31-year-old white woman with hereditary spherocytosis after splenectomy was found to have a central retinal vein occlusion. She had no atherosclerotic risk factors and a negative hypercoaguable workup. Her course was complicated by macular edema. She was treated with intravitreal ranibizumab injections with resultant improvement of her vision and resolution of her macular edema.
Hereditary spherocytosis is an inherited deficiency in erythrocyte membrane proteins that should be considered in younger patients with central retinal vein occlusions because of the disease's impact on hematologic factors. Furthermore, intravitreal antivascular endothelial growth factor injections may improve macular edema in this population.
调查并确定遗传性球形红细胞增多症是否为年轻、健康成年人群发生视网膜中央静脉阻塞的潜在危险因素。
本研究是对一名女性患者的回顾性病例描述。
一名31岁行脾切除术后的患有遗传性球形红细胞增多症的白人女性被发现患有视网膜中央静脉阻塞。她没有动脉粥样硬化危险因素，且高凝检查结果为阴性。她的病程因黄斑水肿而复杂化。她接受了玻璃体内注射雷珠单抗治疗，视力得到改善，黄斑水肿消退。
遗传性球形红细胞增多症是一种红细胞膜蛋白的遗传性缺陷，鉴于该疾病对血液学因素的影响，对于患有视网膜中央静脉阻塞的年轻患者应考虑这一因素。此外，玻璃体内注射抗血管内皮生长因子可能改善该人群的黄斑水肿。
