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一名新冠肺炎患者出现双侧黄斑出血。

Bilateral macular hemorrhage in a patient with COVID-19.

作者信息

D'Aloisio Rossella, Nasillo Vincenzo, Gironi Matteo, Mastropasqua Rodolfo

机构信息

Ophthalmology Clinic, Department of Medicine and Science of Ageing, University G. D'Annunzio Chieti-Pescara, Chieti, Italy.

Section of Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Policlinico, Italy.

出版信息

Am J Ophthalmol Case Rep. 2020 Dec;20:100958. doi: 10.1016/j.ajoc.2020.100958. Epub 2020 Oct 9.

DOI:10.1016/j.ajoc.2020.100958
PMID:33073058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7546668/
Abstract

PURPOSE

We report a case of a patient with a known hereditary spherocytosis who developed a bilateral macular hemorrhage in concurrence with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related respiratory syndrome.

OBSERVATIONS

Blood tests showed severe hemolytic anemia. Interestingly, the peripheral blood smear demonstrated a mixed pathogenesis of the hemolytic process (cold-agglutinin-mediated and non-immune-mediated due to spherocytosis).

CONCLUSIONS AND IMPORTANCE

We argue that SARS-CoV-2 could have triggered the hemolytic process, which led to retinal hemorrhages due to endothelial anoxia from the low oxygen carrying capacity.

摘要

目的

我们报告一例已知患有遗传性球形红细胞增多症的患者，其在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）相关呼吸综合征时并发双侧黄斑出血。

观察结果

血液检查显示严重溶血性贫血。有趣的是，外周血涂片显示溶血过程存在混合发病机制（冷凝集素介导以及由于球形红细胞增多症导致的非免疫介导）。

结论与意义

我们认为SARS-CoV-2可能引发了溶血过程，由于携带氧气能力降低导致内皮缺氧，进而引起视网膜出血。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/7562394/12dbaaecd17d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/7562394/274516ebd949/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/7562394/331124ee0593/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/7562394/12dbaaecd17d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/7562394/274516ebd949/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/7562394/331124ee0593/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/285a/7562394/12dbaaecd17d/gr3.jpg

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