Schoenfeld Andreas A, Harder Dietrich, Poppe Björn, Chofor Ndimofor
Clinic of Radiotherapy and Radiation Oncology-University Clinic of Medical Radiation Physics, Pius-Hospital, Medical Campus of the Carl-von-Ossietzky University of Oldenburg, Ammerländer Heerstraße 114-118, 26129 Oldenburg, Germany.
Phys Med Biol. 2015 Dec 21;60(24):9403-20. doi: 10.1088/0031-9155/60/24/9403. Epub 2015 Nov 18.
Several solid phantom materials have been tested regarding their suitability as water substitutes for dosimetric measurements in brachytherapy with (192)Ir as a typical high energy photon emitter. The radial variations of the spectral photon fluence, of the total, primary and scattered photon fluence and of the absorbed dose to water in the transversal plane of the tested cylindrical phantoms surrounding a centric and coaxially arranged Varian GammaMed afterloading (192)Ir brachytherapy source were Monte-Carlo simulated in EGSnrc. The degree of water equivalence of a phantom material was evaluated by comparing the radial dose-to-water profile in the phantom material with that in water. The phantom size was varied over a large range since it influences the dose contribution by scattered photons with energies diminished by single and multiple Compton scattering. Phantom axis distances up to 10 cm were considered as clinically relevant. Scattered photons with energies reaching down into the 25 keV region dominate the photon fluence at source distances exceeding 3.5 cm. The tested phantom materials showed significant differences in the degree of water equivalence. In phantoms with radii up to 10 cm, RW1, RW3, Solid Water, HE Solid Water, Virtual Water, Plastic Water DT, and Plastic Water LR phantoms show excellent water equivalence with dose deviations from a water phantom not exceeding 0.8%, while Original Plastic Water (as of 2015), Plastic Water (1995), Blue Water, polyethylene, and polystyrene show deviations up to 2.6%. For larger phantom radii up to 30 cm, the deviations for RW1, RW3, Solid Water, HE Solid Water, Virtual Water, Plastic Water DT, and Plastic Water LR remain below 1.4%, while Original Plastic Water (as of 2015), Plastic Water (1995), Blue Water, polyethylene, and polystyrene produce deviations up to 8.1%. PMMA plays a separate role, with deviations up to 4.3% for radii not exceeding 10 cm, but below 1% for radii up to 30 cm. As suggested by the results of the dose simulations and the values of the linear attenuation coefficient, μ, over a large energy range, the balanced content of inorganic additives in a phantom material is regarded as the key feature, providing water equivalence with regard to the attenuation of the primary photons, the release of low-energy photons by Compton scattering, and their attenuation by a combination of the photoelectric and Compton effects.
针对几种固体模体材料作为水替代品在以(192)铱作为典型高能光子发射源的近距离放射治疗剂量测量中的适用性进行了测试。在EGSnrc中对围绕中心且同轴布置的瓦里安伽马医科后装(192)铱近距离放射治疗源的测试圆柱形模体横向平面内的光谱光子注量、总光子注量、初级光子注量和散射光子注量以及水吸收剂量的径向变化进行了蒙特卡罗模拟。通过比较模体材料中的径向水吸收剂量分布与水中的分布来评估模体材料的水等效程度。由于模体尺寸会影响因单次和多次康普顿散射而能量降低的散射光子的剂量贡献,所以模体尺寸在很大范围内变化。高达10厘米的模体轴距离被认为具有临床相关性。能量低至25千电子伏区域的散射光子在源距离超过3.5厘米时主导光子注量。测试的模体材料在水等效程度上显示出显著差异。在半径高达10厘米的模体中,RW1、RW3、固体水、高能量固体水、虚拟水、塑料水DT和塑料水LR模体显示出优异的水等效性,与水模体的剂量偏差不超过0.8%,而原始塑料水(2015年版)、塑料水(1995年版)、蓝水、聚乙烯和聚苯乙烯的偏差高达2.6%。对于半径高达30厘米的更大模体,RW1、RW3、固体水、高能量固体水、虚拟水、塑料水DT和塑料水LR的偏差保持在1.4%以下,而原始塑料水(2015年版)、塑料水(1995年版)、蓝水、聚乙烯和聚苯乙烯产生的偏差高达8.1%。聚甲基丙烯酸甲酯(PMMA)具有独特情况,半径不超过10厘米时偏差高达4.3%,但半径高达30厘米时偏差低于1%。正如剂量模拟结果和在很大能量范围内的线性衰减系数μ值所表明的那样,模体材料中无机添加剂的平衡含量被视为关键特征,在初级光子的衰减、康普顿散射产生的低能光子的释放以及光电效应和康普顿效应共同作用下对这些光子的衰减方面提供水等效性。