College of Science, China Three Gorges University , Yichang 443002, Hubei, China.
National Center for Electron Microscopy, Tsinghua University , 100084 Beijing, China.
ACS Appl Mater Interfaces. 2015 Dec 2;7(47):26017-21. doi: 10.1021/acsami.5b08946. Epub 2015 Nov 18.
Magnetically actuated nanomotor, which swims under externally applied magnetic fields, shows great promise for controlled cargo delivery and release in biological fluids. Here, we report an on-demand release of 6-carboxyfluoresceins (FAM), a green fluorescein, from G-quadruplex DNA functionalized magnetically actuated wormlike nanomotors by applying an alternating magnetic field. This field-triggered FAM releasing process can be easily controlled by multiple parameters such as magnetic field, frequency, and exposure time. In addition, the experimental results and the theoretical simulation demonstrate that both a thermal and a nonthermal mechanism are involved in the cargo releasing process.
磁驱动纳米马达在外磁场的作用下可以游动，有望在生物流体中实现受控的货物输送和释放。在这里，我们通过施加交变磁场，报告了从 G-四链体 DNA 功能化的磁驱动类蠕虫纳米马达中按需释放 6-羧基荧光素（FAM），一种绿色荧光素。这种场触发的 FAM 释放过程可以通过磁场、频率和暴露时间等多个参数来轻松控制。此外，实验结果和理论模拟表明，货物释放过程涉及热和非热两种机制。
