Wong C H
Department of Chemistry, Texas A&M University, College Station 77843.
Science. 1989 Jun 9;244(4909):1145-52. doi: 10.1126/science.2658059.
The synthetic value of enzymes is being increasingly recognized. With an understanding of enzyme-catalyzed reactions and the techniques now available for the low-cost production and rational alteration of enzymes and for the design of new enzymatic activities, biocatalytic synthesis should become one of the most valuable synthetic methods. The fundamental as well as the practical issues of this rapidly growing area are described and its impact on the technology pertaining to synthesis is considered.
酶的合成价值正日益得到认可。随着对酶催化反应以及目前可用于低成本生产、合理改造酶和设计新酶活性的技术的理解,生物催化合成应会成为最有价值的合成方法之一。本文描述了这一快速发展领域的基本问题和实际问题,并探讨了其对合成相关技术的影响。