抗药恶性疟原虫中与哺乳动物多药耐药基因相关的一个基因的扩增
Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.
作者信息
Wilson C M, Serrano A E, Wasley A, Bogenschutz M P, Shankar A H, Wirth D F
机构信息
Department of Tropical Public Health Harvard School of Public Health, Boston, MA 02115.
出版信息
Science. 1989 Jun 9;244(4909):1184-6. doi: 10.1126/science.2658061.
PMID:2658061
Abstract
The malaria parasite Plasmodium falciparum contains at least two genes related to the mammalian multiple drug resistance genes, and at least one of the P. falciparum genes is expressed at a higher level and is present in higher copy number in a strain that is resistant to multiple drugs than in a strain that is sensitive to the drugs.
摘要
疟原虫恶性疟原虫含有至少两个与哺乳动物多药耐药基因相关的基因，并且在对多种药物耐药的菌株中，至少有一个恶性疟原虫基因的表达水平更高，拷贝数也比在对这些药物敏感的菌株中更高。
Zotero 插件