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用于眼科成像的宽带电泵浦1050纳米微机电系统可调谐垂直腔面发射激光器

Wideband Electrically-Pumped 1050 nm MEMS-Tunable VCSEL for Ophthalmic Imaging.

作者信息

John Demis D, Burgner Christopher B, Potsaid Benjamin, Robertson Martin E, Lee Byung Kun, Choi Woo Jhon, Cable Alex E, Fujimoto James G, Jayaraman Vijaysekhar

机构信息

Demis D. John, Martin E. Robertson, Christopher B. Burgner and Vijay Jayaraman are with Praevium Research, Inc., 5385 Hollister Avenue, Suite #211, Santa Barbara, CA 93111, U.S.A. ByungKun Lee, Woo Jhon Choi and James G. Fujimoto are with the Massachusetts Institute of Technology, 50 Vassar Street, Room 36-361, Cambridge, MA 02139, U.S.A. Benjamin Potsaid and Alex Cable are with Thorlabs Inc., 56 Sparta Ave., Newton, New Jersey 07860, U.S.A.

出版信息

J Lightwave Technol. 2015 Aug 15;33(16):3461-3468. doi: 10.1109/JLT.2015.2397860. Epub 2015 Feb 2.

Abstract

In this paper, we present a 1050 nm electrically-pumped micro-electro-mechanically-tunable vertical-cavity-surface-emitting-laser (MEMS-VCSEL) with a record dynamic tuning bandwidth of 63.8 nm, suitable for swept source optical coherence tomography (SS-OCT) imaging. These devices provide reduced cost & complexity relative to previously demonstrated optically pumped devices by obviating the need for a pump laser and associated hardware. We demonstrate ophthalmic SS-OCT imaging with the electrically-pumped MEMS-VCSEL at a 400 kHz axial scan rate for wide field imaging of the in vivo human retina over a 12 mm × 12 mm field and for OCT angiography of the macula over 6 mm × 6 mm & 3 mm × 3 mm fields to show retinal vasculature and capillary structure near the fovea. These results demonstrate the feasibility of electrically pumped MEMS-VCSELs in ophthalmic instrumentation, the largest clinical application of OCT. In addition, we estimate that the 3 dB coherence length in air is 225 meters ± 51 meters, far greater than required for ophthalmic SS-OCT and suggestive of other distance ranging applications.

摘要

在本文中,我们展示了一种1050纳米电泵浦微机电可调垂直腔面发射激光器(MEMS-VCSEL),其动态调谐带宽达到63.8纳米,创历史记录,适用于扫频光源光学相干断层扫描(SS-OCT)成像。与先前展示的光泵浦器件相比,这些器件无需泵浦激光器及相关硬件,从而降低了成本和复杂性。我们展示了利用电泵浦MEMS-VCSEL进行眼科SS-OCT成像,轴向扫描速率为400千赫兹,用于在12毫米×12毫米视野内对活体人视网膜进行宽视野成像,以及在6毫米×6毫米和3毫米×3毫米视野内对黄斑进行OCT血管造影,以显示中央凹附近的视网膜血管系统和毛细血管结构。这些结果证明了电泵浦MEMS-VCSEL在眼科仪器中的可行性,眼科仪器是OCT最大的临床应用领域。此外,我们估计在空气中的3分贝相干长度为225米±51米,远大于眼科SS-OCT所需的长度,这表明其在其他距离测量应用中的潜力。

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本文引用的文献

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Handheld ultrahigh speed swept source optical coherence tomography instrument using a MEMS scanning mirror.
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