An Lin, Wang Ruikang K
Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97237, USA.
Opt Express. 2008 Jul 21;16(15):11438-52. doi: 10.1364/oe.16.011438.
Optical micro-angiography (OMAG), based on Fourier domain optical coherence tomography (OCT), is a recently developed imaging modality that provides dynamic blood flow imaging within microcirculation tissue beds in vivo. This paper presents its first application in imaging the blood circulations in posterior chamber of human eye. To eliminate/minimize the motion artifacts in OMAG flow image caused by the inevitable subject movement, we describe a method to compensate the bulk tissue motion by use of phase changes in sequential OCT A scan signals. By use of a fast OMAG/OCT imaging system at ~840nm wavelength band, we show that OMAG is capable of providing volumetric vasculatural images in retina and choroids, down to capillary level imaging resolution, within approximately 10 s. The depth-resolved volumetric views of the separate retina and choroid vasculatures are also presented. In the end of this paper, we provide a comparison of the OMAG results with those from Doppler OCT and optical coherence angiography.
基于傅里叶域光学相干断层扫描（OCT）的光学微血管造影（OMAG）是一种最近开发的成像方式，可在体内微循环组织床内提供动态血流成像。本文介绍了其在人眼后房血流成像中的首次应用。为了消除/最小化由不可避免的受试者运动引起的OMAG血流图像中的运动伪影，我们描述了一种利用连续OCT A扫描信号中的相位变化来补偿大块组织运动的方法。通过使用波长约为840nm波段的快速OMAG/OCT成像系统，我们表明OMAG能够在大约10秒内提供视网膜和脉络膜的体积血管图像，分辨率可达毛细血管水平成像。还展示了单独的视网膜和脉络膜血管系统的深度分辨体积视图。在本文结尾，我们将OMAG的结果与多普勒OCT和光学相干血管造影的结果进行了比较。
