Franchini Massimo, Mengoli Carlo, Capuzzo Enrico, Terenziani Isabella, Bonfanti Carlo, Lippi Giuseppe
Department of Hematology and Transfusion Medicine, Carlo Poma Hospital, Mantova, Italy.
University of Padova, Padova, Italy.
Semin Thromb Hemost. 2016 Feb;42(1):75-86. doi: 10.1055/s-0035-1564843. Epub 2015 Nov 23.
Although several studies have investigated and confirmed the existence of an association between ABO blood type and several human disorders, especially with cardiovascular disease, little is known on the physiological influence or association of ABO blood groups on basal levels of some conventional hematological and metabolic parameters.
A total number of 7,723 consecutive healthy blood donors underwent laboratory testing at the time of their first blood donation, which apart from ABO typing included assessment of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, total bilirubin, total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), triglycerides, creatinine, iron, ferritin, uric acid, glucose, hemoglobin, and platelet count.
The most relevant finding was the identification of significantly higher values of total cholesterol and HDL-c in subjects with blood group A compared with those with O blood type, with the highest levels being observed in A1 subtype.
The positive association between A blood type and plasma lipid levels supports its potential role in the pathogenesis of atherosclerosis and the clinical observations of increased vulnerability to cardiovascular disease of individuals with non-O blood groups.
尽管多项研究已调查并证实ABO血型与多种人类疾病之间存在关联，尤其是与心血管疾病的关联，但关于ABO血型对某些传统血液学和代谢参数基础水平的生理影响或关联却知之甚少。
共有7723名连续的健康献血者在首次献血时接受了实验室检测，检测项目除ABO血型分型外，还包括丙氨酸转氨酶、天冬氨酸转氨酶、γ-谷氨酰转移酶、总胆红素、总胆固醇、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）、甘油三酯、肌酐、铁、铁蛋白、尿酸、葡萄糖、血红蛋白和血小板计数的评估。
最相关的发现是，与O型血受试者相比，A型血受试者的总胆固醇和HDL-c值显著更高，其中A1亚型的水平最高。
A型血与血浆脂质水平之间的正相关支持了其在动脉粥样硬化发病机制中的潜在作用，以及非O型血个体心血管疾病易感性增加的临床观察结果。
