Departamento de Biología Molecular, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México.
Departamento de Endocrinología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, México.
Biomol Biomed. 2023 Nov 3;23(6):1125-1135. doi: 10.17305/bb.2023.9244.
The role of ABO gene polymorphisms in acute coronary syndrome (ACS) and lipid metabolism is increasingly recognized. We investigated whether ABO gene polymorphisms are significantly associated with ACS and the plasma lipid profile. Six ABO gene polymorphisms (rs651007 T/C, rs579459 T/C, rs495928 T/C, rs8176746 T/G, rs8176740 A/T, and rs512770 T/C) were determined by 5'exonuclease TaqMan assays in 611 patients with ACS and 676 healthy controls. The results demonstrated that the rs8176746 T allele was associated with a lower risk of ACS under the co-dominant, dominant, recessive, over-dominant, and additive models (P = 0.0004, P = 0.0002, P = 0.039, P = 0.0009, and P = 0.0001, respectively). Furthermore, under co-dominant, dominant, and additive models, the rs8176740 A allele was associated with a lower risk of ACS (P = 0.041, P = 0.022, and P = 0.039, respectively). On the other hand, the rs579459 C allele was associated with a lower risk of ACS under the dominant, over-dominant, and additive models (P = 0.025, P = 0.035, and P = 0.037, respectively). In a subanalysis performed with the control group, rs8176746 T and rs8176740 A alleles were associated with low systolic blood pressure and with both high high-density lipoprotein-cholesterol (HDL-C) and low triglyceride plasma concentrations, respectively. In conclusion, ABO gene polymorphisms were associated with a lower risk of ACS, and lower systolic blood pressure and plasma lipid levels, suggesting a causal relationship between ABO blood groups and the incidence of ACS.
ABO 基因多态性在急性冠状动脉综合征 (ACS) 和脂质代谢中的作用正日益受到关注。我们研究了 ABO 基因多态性是否与 ACS 和血浆脂质谱显著相关。通过 5'外切核酸酶 TaqMan 分析，在 611 例 ACS 患者和 676 例健康对照中确定了 6 个 ABO 基因多态性(rs651007T/C、rs579459T/C、rs495928T/C、rs8176746T/G、rs8176740A/T 和 rs512770T/C)。结果表明，rs8176746T 等位基因在共显性、显性、隐性、超显性和加性模型下与 ACS 的风险降低相关(P=0.0004、P=0.0002、P=0.039、P=0.0009 和 P=0.0001)。此外，在共显性、显性和加性模型下，rs8176740A 等位基因与 ACS 的风险降低相关(P=0.041、P=0.022 和 P=0.039)。另一方面，rs579459C 等位基因在显性、超显性和加性模型下与 ACS 的风险降低相关(P=0.025、P=0.035 和 P=0.037)。在对对照组进行的亚分析中，rs8176746T 和 rs8176740A 等位基因分别与较低的收缩压和较高的高密度脂蛋白胆固醇(HDL-C)和较低的甘油三酯血浆浓度相关。总之，ABO 基因多态性与 ACS 的风险降低以及较低的收缩压和血浆脂质水平相关，提示 ABO 血型与 ACS 的发病之间存在因果关系。
