Navia J M, Lopez H
J Dent Res. 1977 Mar;56(3):222-7. doi: 10.1177/00220345770560030501.
A factorial design (2x2) was used to study the caries effect of two diets (starch based versus stock) fed to rat dams and their litters, and also of variations in the weaning age (19 versus 25 days). Higher and reproducible caries scores were obtained in rats which were fed a purified starch-based diet, weaned at 19 days of age, and subsequently given a cariogenic challenge.
采用析因设计（2×2）研究了两种饮食（淀粉基饮食与常规饮食）对大鼠母鼠及其幼崽的致龋作用，以及断奶年龄差异（19天与25天）的影响。在喂食纯化淀粉基饮食、19日龄断奶并随后接受致龋刺激的大鼠中获得了更高且可重复的龋病评分。
