FCE 22101及其口服可用酯FCE 22891的合成与抗菌谱
Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.
作者信息
Franceschi G, Perrone E, Alpegiani M, Bedeschi A, Battistini C, Zarini F, Della Bruna C
机构信息
Farmitalia Carlo Erba, Research and Development, Milan, Italy.
出版信息
J Antimicrob Chemother. 1989 Mar;23 Suppl C:1-6. doi: 10.1093/jac/23.suppl_c.1.
PMID:2659569
Abstract
The most efficient routes for the synthesis of FCE 22101, a penem antibiotic characterized by a carbamoyloxymethyl sidechain at C-2 identical to that of cefuroxime and cefotaxime, and of FCE 22891, its orally absorbed pro-drug, are described. On the basis of in-vitro antimicrobial profile and other characteristics the compounds have been considered worthy of further development.
摘要
本文描述了合成FCE 22101及其口服吸收前体药物FCE 22891的最有效路线。FCE 22101是一种青霉烯类抗生素，其C-2位的氨甲酰氧基甲基侧链与头孢呋辛和头孢噻肟的相同。基于体外抗菌谱和其他特性，这些化合物被认为值得进一步开发。
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