Ben Abdallah Kolsi Rihab, Ben Gara Amel, Chaaben Rim, El Feki Abdelfattah, Patti Francesco Paolo, El Feki Lotfi, Belghith Karima
a Laboratory of Plant Biotechnology , Faculty of Sciences of Sfax , Sfax , Tunisia .
d Stazione Zoologica 'A. Dohrn', Functional and Evolutionary Ecology Laboratory , Punta S. Pietro, Ischia (Naples) , Italy .
Arch Physiol Biochem. 2015;121(5):210-7. doi: 10.3109/13813455.2015.1105266. Epub 2015 Nov 24.
This study aims to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on lipase activity in vitro and in vivo to high fat diet (HFD)-rats on body weight, lipid profile and liver-kidney functions. The administration of CNSP decreases the body weight and inhibits lipase activity of obese rats in serum and intestine as compared with untreated HDF-rats. This decrease in lipase activity leads to lipid regulation shown by the decrease of total cholesterol (T-Ch), triglycerides (TG) and low density lipoprotein cholesterol (LDL-C) and an increase in high density lipoprotein cholesterol (HDL-C) levels in HFD-rats. Additionally, CNSP administration to HFD-rats induces anti-oxidant activity observed by the increase of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) activities and the decrease in Thiobarbituric acid reactive substances (TBARS) levels and protects liver-kidney functions proven by a decrease in the levels of toxicity parameters in blood.
本研究旨在首次评估结节藻硫酸化多糖（CNSP）对高脂饮食（HFD）大鼠体外和体内脂肪酶活性、体重、血脂谱以及肝肾 功能的影响。与未处理的HFD大鼠相比，给予CNSP可降低肥胖大鼠的体重，并抑制其血清和肠道中的脂肪酶活性。脂肪酶活性的降低导致脂质调节，表现为HFD大鼠的总胆固醇（T-Ch）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平降低，高密度脂蛋白胆固醇（HDL-C）水平升高。此外，给予HFD大鼠CNSP可诱导抗氧化活性，表现为超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPX）活性增加，硫代巴比妥酸反应性物质（TBARS）水平降低，并通过降低血液中毒性参数水平来保护肝肾 功能。
