Ghanbari Ghozikali Mohammad, Heibati Behzad, Naddafi Kazem, Kloog Itai, Oliveri Conti Gea, Polosa Riccardo, Ferrante Margherita
Tabriz Health Services Management Research Center, Department of Environmental Health Engineering, East Azerbaijan Province Health Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Environmental Health Engineering, School of Public Health and Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran, Iran.
Department of Occupational Health Engineering, Faculty of Health and Health Sciences Research Center, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Environ Res. 2016 Jan;144(Pt A):99-105. doi: 10.1016/j.envres.2015.10.030. Epub 2015 Nov 21.
Chronic obstructive pulmonary disease (COPD) is an important disease worldwide characterized by chronically poor airflow. The economic burden of COPD on any society can be enormous if not managed. We applied the approach proposed by the World Health Organization (WHO) using the AirQ2.2.3 software developed by the WHO European Center for Environment and Health on air pollutants in Tabriz (Iran) (2011-2012 year). A 1h average of concentrations of ozone (O3), daily average concentrations of nitrogen dioxide (NO2) and sulfur dioxide (SO2) were used to assess human exposure and health effect in terms of attributable proportion of the health outcome and annual number of excess cases of Hospital Admissions for COPD (HA COPD). The results of this study showed that 2% (95% CI: 0.8-3.1%) of HA COPD were attributed to O3 concentrations over 10 μg/m(3). In addition, 0.7 % (95% CI: 0.1-1.8%) and 0.5% (95% CI: 0-1%) of HA COPD were attributed to NO2 and SO2 concentrations over 10 μg/m(3) respectively. In this study, we have shown that O3, NO2 and SO2 have a significant impact on COPD hospitalization. Given these results the policy decisions are needed in order to reduce the chronic pulmonary diseases caused by air pollution and furthermore better quantification studies are recommended.
慢性阻塞性肺疾病(COPD)是一种在全球范围内较为重要的、以长期气流受限为特征的疾病。若管理不善,COPD给任何社会带来的经济负担都可能是巨大的。我们采用了世界卫生组织(WHO)提出的方法,运用WHO欧洲环境与健康中心开发的AirQ2.2.3软件,对伊朗大不里士(2011 - 2012年)的空气污染物进行了分析。采用臭氧(O3)1小时平均浓度、二氧化氮(NO2)和二氧化硫(SO2)日平均浓度,从健康结局的归因比例和慢性阻塞性肺疾病住院(HA COPD)超额病例数两方面评估人群暴露和健康影响。本研究结果表明,2%(95%置信区间:0.8 - 3.1%)的HA COPD归因于O3浓度超过10μg/m³。此外,分别有0.7%(95%置信区间:0.1 - 1.8%)和0.5%(95%置信区间:0 - 1%)的HA COPD归因于NO2和SO2浓度超过10μg/m³。在本研究中,我们表明O3、NO2和SO2对COPD住院有显著影响。鉴于这些结果,需要做出政策决策以减少空气污染导致的慢性肺部疾病,此外,建议开展更好的定量研究。