尽管存在急性睡眠剥夺，脑源性神经营养因子（BDNF）是否参与维持认知表现的代偿机制？一项探索性研究。

Could BDNF be involved in compensatory mechanisms to maintain cognitive performance despite acute sleep deprivation? An exploratory study.

作者信息

Giacobbo Bruno Lima, Corrêa Márcio Silveira, Vedovelli Kelem, de Souza Carlos Eduardo Bruhn, Spitza Letícia Martins, Gonçalves Lucas, Paludo Nathália, Molina Rachel Dias, da Rosa Eduarda Dias, Argimon Irani Iracema de Lima, Bromberg Elke

机构信息

Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil; National Institute for Translational Medicine (INCT-TM), Porto Alegre, Rio Grande do Sul 90035-003, Brazil.

Neurobiology and Developmental Biology Laboratory, Faculty of Biosciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil; Institute of Geriatrics and Gerontology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil; National Institute for Translational Medicine (INCT-TM), Porto Alegre, Rio Grande do Sul 90035-003, Brazil.

出版信息

Int J Psychophysiol. 2016 Jan;99:96-102. doi: 10.1016/j.ijpsycho.2015.11.008. Epub 2015 Nov 19.

DOI:10.1016/j.ijpsycho.2015.11.008

PMID:26602839

Abstract

BACKGROUND

Neuroimaging studies suggest that acute sleep deprivation can lead to adaptations, such as compensatory recruitment of cerebral structures, to maintain cognitive performance despite sleep loss. However, the understanding of the neurochemical alterations related to these adaptations remains incomplete.

OBJECTIVE

Investigate BDNF levels, cognitive performance and their relations in healthy subjects after acute sleep deprivation.

METHODS

Nineteen sleep deprived (22.11±3.21years) and twenty control (25.10±4.42years) subjects completed depression, anxiety and sleep quality questionnaires. Sleep deprived group spent a full night awake performing different playful activities to keep themselves from sleeping. Attention, response inhibition capacity and working memory (prefrontal cortex-dependent) were assessed with Stroop and Digit Span tests. Declarative memory (hippocampus-dependent) was assessed with Logical Memory test. Serum BDNF was measured by sandwich ELISA. Data were analyzed with independent samples T-test, ANOVA, ANCOVA and curve estimation regressions. p<0.05 was deemed statistically significant.

RESULTS

The sleep deprived group showed higher BDNF levels and normal performance on attention, response inhibition capacity and working memory. However, declarative memory was impaired. A sigmoidal relation between BDNF and Stroop Test scores was found.

CONCLUSIONS

Increased BDNF could be related, at least in part, to the maintenance of normal prefrontal cognitive functions after sleep deprivation. This potential relation should be further investigated.

摘要

背景

神经影像学研究表明，急性睡眠剥夺可导致适应性变化，如大脑结构的代偿性募集，以在睡眠缺失的情况下维持认知表现。然而，对于与这些适应性变化相关的神经化学改变的理解仍不完整。

目的

研究急性睡眠剥夺后健康受试者的脑源性神经营养因子（BDNF）水平、认知表现及其关系。

方法

19名睡眠剥夺受试者（22.11±3.21岁）和20名对照受试者（25.10±4.42岁）完成了抑郁、焦虑和睡眠质量问卷。睡眠剥夺组通宵保持清醒，进行不同的娱乐活动以防止入睡。通过Stroop测试和数字广度测试评估注意力、反应抑制能力和工作记忆（依赖前额叶皮质）。通过逻辑记忆测试评估陈述性记忆（依赖海马体）。采用夹心酶联免疫吸附测定法测量血清BDNF。数据采用独立样本t检验、方差分析、协方差分析和曲线估计回归进行分析。p<0.05被认为具有统计学意义。