非洲中部加蓬孕妇中无乳链球菌血清型分布及抗菌药物敏感性
Streptococcus agalactiae Serotype Distribution and Antimicrobial Susceptibility in Pregnant Women in Gabon, Central Africa.
作者信息
Belard Sabine, Toepfner Nicole, Capan-Melser Mesküre, Mombo-Ngoma Ghyslain, Zoleko-Manego Rella, Groger Mirjam, Matsiegui Pierre-Blaise, Agnandji Selidji T, Adegnika Ayôla A, González Raquel, Kremsner Peter G, Menendez Clara, Ramharter Michael, Berner Reinhard
机构信息
Centre de Recherches Médicales de Lambaréné, Hôpital Albert Schweitzer, Lambaréné, Gabon.
Institut für Tropenmedizin, Universität Tübingen, Tübingen, Germany.
出版信息
Sci Rep. 2015 Nov 25;5:17281. doi: 10.1038/srep17281.
Abstract
Neonatal invasive disease due to Streptococcus agalactiae is life threatening and preventive strategies suitable for resource limited settings are urgently needed. Protective coverage of vaccine candidates based on capsular epitopes will relate to local epidemiology of S. agalactiae serotypes and successful management of critical infections depends on timely therapy with effective antibiotics. This is the first report on serotype distribution and antimicrobial susceptibility of S. agalactiae in pregnant women from a Central African region. Serotypes V, III, and Ib accounted for 88/109 (81%) serotypes and all isolates were susceptible to penicillin and clindamycin while 13% showed intermediate susceptibility to erythromycin.
摘要
无乳链球菌引起的新生儿侵袭性疾病会危及生命，因此迫切需要适用于资源有限地区的预防策略。基于荚膜表位的候选疫苗的保护覆盖率将与无乳链球菌血清型的当地流行病学相关，而关键感染的成功管理取决于及时使用有效的抗生素进行治疗。这是关于中非地区孕妇无乳链球菌血清型分布和抗菌药物敏感性的首份报告。血清型V、III和Ib占109株血清型中的88株（81%），所有分离株对青霉素和克林霉素敏感，而13%的分离株对红霉素表现出中度敏感性。
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