外周组织中巨噬细胞发育和功能的调控。
Regulation of macrophage development and function in peripheral tissues.
作者信息
Lavin Yonit, Mortha Arthur, Rahman Adeeb, Merad Miriam
机构信息
Department of Oncological Sciences, Tisch Cancer Institute and the Immunology Institute, Icahn School of Medicine at Mount Sinai, New York City, New York 10029, USA.
出版信息
Nat Rev Immunol. 2015 Dec;15(12):731-44. doi: 10.1038/nri3920.
Abstract
Macrophages are immune cells of haematopoietic origin that provide crucial innate immune defence and have tissue-specific functions in the regulation and maintenance of organ homeostasis. Recent studies of macrophage ontogeny, as well as transcriptional and epigenetic identity, have started to reveal the decisive role of the tissue stroma in the regulation of macrophage function. These findings suggest that most macrophages seed the tissues during embryonic development and functionally specialize in response to cytokines and metabolites that are released by the stroma and drive the expression of unique transcription factors. In this Review, we discuss how recent insights into macrophage ontogeny and macrophage-stroma interactions contribute to our understanding of the crosstalk that shapes macrophage function and the maintenance of organ integrity.
摘要
巨噬细胞是造血来源的免疫细胞，提供关键的先天性免疫防御，并在器官稳态的调节和维持中具有组织特异性功能。最近关于巨噬细胞个体发育以及转录和表观遗传特征的研究，已开始揭示组织基质在巨噬细胞功能调节中的决定性作用。这些发现表明，大多数巨噬细胞在胚胎发育期间定植于组织中，并在功能上专门响应由基质释放并驱动独特转录因子表达的细胞因子和代谢产物。在本综述中，我们讨论了最近对巨噬细胞个体发育和巨噬细胞-基质相互作用的见解如何有助于我们理解塑造巨噬细胞功能和维持器官完整性的相互作用。
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