遵循世界癌症研究基金会/美国癌症研究学会的建议与胰腺癌风险
Adherence to World Cancer Research Fund/American Institute for Cancer Research recommendations and pancreatic cancer risk.
作者信息
Lucas Aimee L, Bravi Francesca, Boffetta Paolo, Polesel Jerry, Serraino Diego, La Vecchia Carlo, Bosetti Cristina
机构信息
Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, NY, USA.
Department of Epidemiology, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri"-IRCCS, Milan, Italy.
出版信息
Cancer Epidemiol. 2016 Feb;40:15-21. doi: 10.1016/j.canep.2015.10.026. Epub 2015 Nov 21.
BACKGROUND
Pancreatic cancer is a leading cause of cancer death. A role of dietary factors in pancreatic carcinogenesis has been suggested. The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) published 8 recommendations for cancer prevention. We evaluated the effect of adherence to the WCRF/AICR recommendations on pancreatic cancer risk.
METHODS
We operationalized 7 of the 8 WCRF/AICR recommendations to generate a WCRF/AICR score. We examined the association of WCRF/AICR score with pancreatic cancer in data from an Italian case-control study of 326 incident cases and 652 controls.
RESULTS
Adherence to WCRF/AICR recommendations was associated with a significantly decreased risk of pancreatic cancer. Using a WCRF/AICR score <3.5 as a reference, the adjusted odds ratio (OR) for a score 3.5-<4 was 0.80 (95% CI 0.49, 1.28), for a score 4-<5 0.54 (95% CI 0.35, 0.82), and for score 5 or more 0.41 (95% CI 0.24, 0.68; p-value for trend 0.0002). The OR for a continuous increment of one unit of the WCRF/AICR score was 0.72 (95% CI 0.60, 0.87).
CONCLUSION
Adherence to the WCRF/AICR recommendations may reduce pancreatic cancer risk.
背景
胰腺癌是癌症死亡的主要原因之一。饮食因素在胰腺癌发生过程中的作用已被提出。世界癌症研究基金会（WCRF）和美国癌症研究学会（AICR）发布了8条癌症预防建议。我们评估了遵循WCRF/AICR建议对胰腺癌风险的影响。
方法
我们将WCRF/AICR的8条建议中的7条进行操作化处理，以生成一个WCRF/AICR评分。我们在一项意大利病例对照研究的数据中，研究了WCRF/AICR评分与胰腺癌之间的关联，该研究包括326例新发病例和652例对照。
结果
遵循WCRF/AICR建议与胰腺癌风险显著降低相关。以WCRF/AICR评分<3.5作为参照，评分3.5-<4时的调整比值比（OR）为0.80（95%置信区间0.49，1.28），评分4-<5时为0.54（95%置信区间0.35，0.82），评分5及以上时为0.41（95%置信区间0.24，0.68；趋势p值为0.0002）。WCRF/AICR评分每连续增加一个单位，OR为0.72（95%置信区间0.60，0.87）。
结论
遵循WCRF/AICR建议可能降低胰腺癌风险。
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