Bravi Francesca, Polesel Jerry, Garavello Werner, Serraino Diego, Negri Eva, Franchin Gianni, La Vecchia Carlo, Bosetti Cristina
Dipartimento di Epidemiologia, IRCCS - Istituto di Ricerche Farmacologiche "Mario Negri", via G. La Masa 19, 20156 Milan, Italy.
S.O.C. Epidemiologia Oncologica, CRO Aviano National Cancer Institute, via F. Gallini 2, 33081 Aviano (PN), Italy.
Oral Oncol. 2017 Jan;64:59-64. doi: 10.1016/j.oraloncology.2016.11.012. Epub 2016 Dec 3.
The World Cancer Research Fund (WCRF) and the American Institute for Cancer Research (AICR) have proposed eight recommendations for cancer prevention, related to body fatness, diet, and physical activity. Our aim is to evaluate the role of adherence to these recommendations on head and neck cancers risk.
We obtained an overall score including seven of the WCRF/AICR recommendations, and examined its relationship with head and neck cancers risk in two Italian case-control studies including 946 patients with oral cavity and pharyngeal (OCP) cancer and 2492 controls, and 689 patients with laryngeal cancer and 1605 controls.
Higher adherence to WCRF/AICR recommendations was associated to a reduced risk of OCP cancer (odds ratio, OR=0.45, 95% confidence interval, CI: 0.33-0.62 for a score of 4-<5, and OR=0.32, 95% CI: 0.22-0.49 for a score of ⩾5 as compared to <3). The ORs for laryngeal cancer were 0.68 (95% CI: 0.50-0.92) for a score of 3-<4, 0.39 (95% CI: 0.28-0.55) for a score of 4-<5, and 0.24 (95% CI: 0.15-0.38) for a score of ⩾5.
Our study indicates that high adherence to the WCRF/AICR recommendations for cancer prevention is associated with a substantially decreased risk of head and neck cancers.
世界癌症研究基金会（WCRF）和美国癌症研究学会（AICR）提出了八项癌症预防建议，涉及身体脂肪、饮食和体育活动。我们的目的是评估遵守这些建议对头颈癌风险的作用。
我们得出了一个包含WCRF/AICR七项建议的综合评分，并在两项意大利病例对照研究中检验了该评分与头颈癌风险的关系。这两项研究包括946例口腔和咽癌（OCP）患者及2492例对照，以及689例喉癌患者及1605例对照。
更高程度地遵守WCRF/AICR建议与OCP癌风险降低相关（比值比，OR = 0.45，95%置信区间，CI：评分为4 - <5时为0.33 - 0.62，评分为⩾5时与<3相比OR = 0.32，95% CI：0.22 - 0.49）。喉癌的OR值在评分为3 - <4时为0.68（95% CI：0.50 - 0.92），评分为4 - <5时为0.39（95% CI：0.28 - 0.55），评分为⩾5时为0.24（95% CI：0.15 - 0.38）。
我们的研究表明，高度遵守WCRF/AICR癌症预防建议与头颈癌风险大幅降低相关。
