School of Medicine, Jiangsu University, Zhenjiang, People's Republic of China.
Department of Clinical Laboratory, Affiliated Yancheng Hospital, School of Medicine, Southeast University, Yancheng, Jiangsu, People's Republic of China.
Int J Nanomedicine. 2015 Nov 6;10:6943-53. doi: 10.2147/IJN.S82778. eCollection 2015.
X-ray computed tomography (CT) is the most commonly used imaging technique for noninvasive diagnosis of disease. In order to improve tissue specificity and prevent adverse effects, we report the design and synthesis of iodine-doped carbon dots (I-doped CDs) as efficient CT contrast agents and fluorescence probe by a facile bottom-up hydrothermal carbonization process. The as-prepared I-doped CDs are monodispersed spherical nanoparticles (a diameter of ~2.7 nm) with favorable dispersibility and colloidal stability in water. The aqueous solution of I-doped CDs showed wavelength-dependent excitation and stable photoluminescence similar to traditional carbon quantum dots. Importantly, I-doped CDs displayed superior X-ray attenuation properties in vitro and excellent biocompatibility. After intravenous injection, I-doped CDs were distributed throughout the body and excreted by renal clearance. These findings validated that I-doped CDs with high X-ray attenuation potency and favorable photoluminescence show great promise for biomedical research and disease diagnosis.
X 射线计算机断层扫描（CT）是用于疾病无创诊断的最常用成像技术。为了提高组织特异性并预防不良反应，我们报告了碘掺杂碳点（I-doped CDs）的设计和合成，其作为高效 CT 造影剂和荧光探针通过简便的自上而下的水热碳化过程。所制备的 I-doped CDs 是单分散的球形纳米颗粒（直径约为 2.7nm），在水中具有良好的分散性和胶体稳定性。I-doped CDs 的水溶液表现出与传统碳量子点相似的波长依赖性激发和稳定的光致发光。重要的是，I-doped CDs 在体外表现出优异的 X 射线衰减性能和良好的生物相容性。静脉注射后，I-doped CDs 分布于全身并通过肾脏清除。这些发现验证了具有高 X 射线衰减能力和良好光致发光的 I-doped CDs 在生物医学研究和疾病诊断方面具有广阔的应用前景。
