Waller Lisa P, Deshpande Vrushak, Pyrsopoulos Nikolaos
Lisa P Waller, Vrushak Deshpande, Nikolaos Pyrsopoulos, Division of Gastroenterology and Hepatology, Rutgers New Jersey Medical School, Newark, NJ 07103, United States.
World J Hepatol. 2015 Nov 18;7(26):2648-63. doi: 10.4254/wjh.v7.i26.2648.
Hepatocellular carcinoma (HCC) is rapidly becoming one of the most prevalent cancers worldwide. With a rising rate, it is a prominent source of mortality. Patients with advanced fibrosis, predominantly cirrhosis and hepatitis B are predisposed to developing HCC. Individuals with chronic hepatitis B and C infections are most commonly afflicted. Different therapeutic options, including liver resection, transplantation, systemic and local therapy, must be tailored to each patient. Liver transplantation offers leading results to achieve a cure. The Milan criteria is acknowledged as the model to classify the individuals that meet requirements to undergo transplantation. Mean survival remains suboptimal because of long waiting times and limited donor organ resources. Recent debates involve expansion of these criteria to create options for patients with HCC to increase overall survival.
肝细胞癌（HCC）正迅速成为全球最常见的癌症之一。随着发病率的上升，它是一个突出的死亡原因。晚期纤维化患者，主要是肝硬化和乙型肝炎患者，易患HCC。慢性乙型和丙型肝炎感染的个体最常受到影响。不同的治疗选择，包括肝切除、移植、全身和局部治疗，必须根据每个患者量身定制。肝移植提供了实现治愈的领先结果。米兰标准被公认为对符合移植要求的个体进行分类的模型。由于等待时间长和供体器官资源有限，平均生存率仍然不理想。最近的争论涉及扩大这些标准，为HCC患者创造选择以提高总体生存率。
