Christensen J A, Bohle A, Mikeler E, Taugner R
Gade Institute, Department of Pathology, University of Bergen, Norway.
Cell Tissue Res. 1989 Jan;255(1):149-53. doi: 10.1007/BF00229076.
It is difficult to distinguish between Goormaghtigh cells (G-cells) and media cells of the glomerular arterioles at the border of the Goormaghtigh cell field. Consequently, it has been unclear whether renin-positive G-cells are normally present and also whether renin-producing cells are recruited from the pool of renin-negative G-cells upon stimulation of the renin-angiotensin system (RAS). In the present study, immunohistochemical and electron-microscopic experiments have been carried out on serially sectioned kidney biopsies from four patients with pseudo-Bartter syndrome. The results strongly suggest that with long-lasting stimulation of the RAS all renin-negative ("secretory resting") G-cells are ultimately converted into renin-producing granular cells.
在球旁细胞（G细胞）区域边界处，很难区分球旁细胞（G细胞）和肾小球小动脉的中层细胞。因此，目前尚不清楚肾素阳性的G细胞是否正常存在，以及在肾素-血管紧张素系统（RAS）受刺激时，产生肾素的细胞是否从肾素阴性的G细胞池中募集而来。在本研究中，对4例假性巴特综合征患者的连续肾脏活检组织进行了免疫组织化学和电子显微镜实验。结果有力地表明，随着RAS的长期刺激，所有肾素阴性（“分泌静止”）的G细胞最终都会转化为产生肾素的颗粒细胞。
