Kocer Armagan
University of Groningen, University Medical Center Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands.
Curr Opin Chem Biol. 2015 Dec;29:120-7. doi: 10.1016/j.cbpa.2015.10.006. Epub 2015 Nov 21.
Sensing and responding to mechanical stimuli is an ancient behavior and ubiquitous to all forms of life. One of its players 'mechanosensitive ion channels' are involved in processes from osmosensing in bacteria to pain in humans. However, the mechanism of mechanosensing is yet to be elucidated. This review describes recent developments in the understanding of a bacterial mechanosensitive channel. Force from the lipid principle of mechanosensation, new methods to understand protein-lipid interactions, the role of water in the gating, the use of engineered mechanosensitive channels in the understanding of the gating mechanism and application of the accumulated knowledge in the field of drug delivery, drug design and sensor technologies are discussed.
感知和响应机械刺激是一种古老的行为，在所有生命形式中普遍存在。其中一个参与者“机械敏感离子通道”涉及从细菌的渗透压感知到人类疼痛等各种过程。然而，机械传感的机制尚待阐明。本综述描述了在理解细菌机械敏感通道方面的最新进展。讨论了来自机械传感脂质原理的力、理解蛋白质-脂质相互作用的新方法、水在门控中的作用、利用工程化机械敏感通道理解门控机制以及将积累的知识应用于药物递送、药物设计和传感器技术领域。
