Baumbauer Kyle M, Young Erin E, Starkweather Angela R, Guite Jessica W, Russell Beth S, Manworren Renee C B
School of Nursing, The Center for Advancing Management of Pain, University of Connecticut, Storrs, CT 06269-4026, USA; Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT 06030, USA; Institute for Systems Genomics, University of Connecticut Health Center, 400 Farmington Ave, CT 06030, USA.
School of Nursing, The Center for Advancing Management of Pain, University of Connecticut, Storrs, CT 06269-4026, USA; Institute for Systems Genomics, University of Connecticut Health Center, 400 Farmington Ave, CT 06030, USA; Department of Genetics and Genome Sciences, University of Connecticut Health Center, 400 Farmington Ave, Farmington, CT 06030, USA.
Med Clin North Am. 2016 Jan;100(1):183-97. doi: 10.1016/j.mcna.2015.08.013.
In the adult population chronic pain can lead to loss of productivity and earning potential, and decreased quality of life. There are distinct groups with increased vulnerability for the emergence of chronic pain. These groups may be defined by developmental status and/or life circumstances. Within the pediatric, geriatric, and drug abuser populations, chronic pain represents a significant health issue. This article focuses on known anatomic, physiologic, and genetic mechanisms underlying chronic pain in these populations, and highlights the need for a multimodal approach from multiple health care professionals for management of chronic pain in those with the most risk.
在成年人群中，慢性疼痛会导致生产力和收入潜力的丧失，以及生活质量的下降。有一些不同的群体，他们出现慢性疼痛的易感性增加。这些群体可以根据发育状况和/或生活环境来界定。在儿科、老年科和药物滥用者群体中，慢性疼痛是一个重大的健康问题。本文重点关注这些群体中慢性疼痛背后已知的解剖学、生理学和遗传学机制，并强调需要多学科医疗专业人员采取多模式方法来管理那些风险最高人群的慢性疼痛。
