Anderson Megan E
Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA; Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.
Orthop Clin North Am. 2016 Jan;47(1):283-92. doi: 10.1016/j.ocl.2015.08.022.
Osteosarcoma is the most common primary bone malignancy in children. Treatment has evolved to include systemic chemotherapy and local control surgery. Although survival improved initially in a drastic fashion with this approach, recent decades have seen little to no further gains in this area. Limb salvage surgery evolved with effective chemotherapy and advances in imaging, and continues to improve in the recent era. This article serves as a review of survival in high-grade osteosarcoma: prognostic factors, advances in chemotherapy and surgery, late effects of chemotherapy and surgery in survivors, and future directions.
骨肉瘤是儿童中最常见的原发性骨恶性肿瘤。治疗方法已发展为包括全身化疗和局部控制手术。尽管采用这种方法最初生存率有了显著提高，但近几十年来在这一领域几乎没有进一步的进展。保肢手术随着有效的化疗和影像学的进步而发展，并且在最近一个时期仍在不断改进。本文对高级别骨肉瘤的生存情况进行综述：预后因素、化疗和手术的进展、幸存者化疗和手术的晚期影响以及未来方向。
