He Haibing, Ma Zhongjun, Wang Qianqian, Liu Yu, Xu Hualin
a Institute of Marine Biology & Natural Products, Ocean College , Zhejiang University , Hangzhou , China.
b State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences , Zhejiang University , Hangzhou , China.
Nat Prod Res. 2016 Jul;30(13):1526-31. doi: 10.1080/14786419.2015.1116000. Epub 2015 Nov 30.
A new eremophilane sesquiterpene, capnodiumone (1), along with five known eremophilane sesquiterpenes (2-6) and eight other compounds (7-14), have been isolated from a mangrove-associated fungus Capnodium sp. SZ-F22. The chemical structures were elucidated on the basis of extensive spectroscopic analysis. The broth extract of the fungus exhibited a good inhibitory effect on the mycelium growth against Fusarium graminearum at 100 μg/mL, however, all the 14 compounds showed no expected antifungal activity. The probable reasons were discussed.
从一种与红树林相关的真菌多主棒孢菌Capnodium sp. SZ-F22中分离出一种新的桉烷倍半萜——多主棒孢菌素（1），以及五种已知的桉烷倍半萜（2 - 6）和其他八种化合物（7 - 14）。通过广泛的光谱分析阐明了其化学结构。该真菌的发酵液提取物在浓度为100μg/mL时对禾谷镰刀菌的菌丝生长表现出良好的抑制作用，然而，所有这14种化合物均未显示出预期的抗真菌活性。文中讨论了可能的原因。
