来自夏威夷内生真菌Chaetoconis sp. FT087的桉烷倍半萜。
Eremophilane sesquiterpenes from Hawaiian endophytic fungus Chaetoconis sp. FT087.
作者信息
Li Chun-Shun, Ding Yuanqing, Yang Bao-Jun, Hoffman Naomi, Yin Hong-Quan, Mahmud Taifo, Turkson James, Cao Shugeng
机构信息
Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, 34 Rainbow Drive, Hilo, HI 96720, USA; Natural Products and Experimental Therapeutics, Cancer Center, University of Hawai'i, 701 Ilalo Street, Honolulu, HI 96813, USA.
National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
出版信息
Phytochemistry. 2016 Jun;126:41-6. doi: 10.1016/j.phytochem.2016.03.005. Epub 2016 Mar 16.
Seven sesquiterpene derivatives, including chaetopenoids A-F and dendryphiellin A1, and 6-methyl-(2E, 4E, 6S) octadienoic acid were isolated from the culture broth of Chaetoconis sp. FT087. Their structures were determined through the analysis of HRMS and NMR spectroscopic data. The absolute configurations of chaetopenoids A-D were elucidated by comparison of their CD and optical rotation data with those in the literature. Chaetopenoids A-C and E belong to the eremophilane type of sesquiterpenoids, while chaetopenoids D and F and dendryphiellin A1 have a trinor-eremophilane skeleton. All compounds were tested against A2780 and cisplatin resistant A2780CisR cell lines, and dendryphiellin A1 was moderately active with IC50 values of 6.6 and 9.1 μg/mL, respectively.
从Chaetoconis sp. FT087的培养液中分离出7种倍半萜衍生物，包括chaetopenoids A - F和dendryphiellin A1，以及6 - 甲基 - (2E, 4E, 6S) 辛二烯酸。通过高分辨质谱（HRMS）和核磁共振（NMR）光谱数据分析确定了它们的结构。通过将chaetopenoids A - D的圆二色光谱（CD）和旋光数据与文献中的数据进行比较，阐明了它们的绝对构型。Chaetopenoids A - C和E属于桉叶烷型倍半萜，而chaetopenoids D和F以及dendryphiellin A1具有降桉叶烷骨架。所有化合物均针对A2780和顺铂耐药的A2780CisR细胞系进行了测试，dendryphiellin A1具有中等活性，IC50值分别为6.6和9.1 μg/mL。
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