Liu Jimei, Zhang Dewu, Zhang Min, Zhao Jinlian, Chen Ridao, Wang Nan, Zhang Dan, Dai Jungui
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
J Nat Prod. 2016 Sep 23;79(9):2229-35. doi: 10.1021/acs.jnatprod.6b00299. Epub 2016 Jul 19.
Nine new polyoxygenated eremophilane sesquiterpenes, periconianones C-K (1-9), including one unusual isoeremophilane sesquiterpene, periconianone C (1), and four trinor-eremophilane sesquiterpenes, periconianones H-K (6-9), were isolated from the endophytic fungus Periconia sp. F-31. Compound 1 is the first furan-type isoeremophilane reported containing a linkage of C-8/C-11 and a 7,12-epoxy moiety. These compound structures, including absolute configurations, were elucidated through extensive spectroscopic data analysis, electronic circular dichroism, Mo2(AcO)4-induced circular dichroism, and single-crystal X-ray diffraction (Cu Kα). Compounds 2, 5, and 9 showed inhibition effects on lipopolysaccharide-induced NO production in BV2 cells by 10.2%, 18.3%, and 16.1% at a concentration of 1.0 μM, respectively, which is comparable to the positive control curcumin (12.9% at 1.0 μM).
从内生真菌Periconia sp. F-31中分离出9种新的多氧化苦艾烷倍半萜，即佩里科尼酮C-K（1-9），其中包括一种不寻常的异苦艾烷倍半萜佩里科尼酮C（1），以及4种降苦艾烷倍半萜，佩里科尼酮H-K（6-9）。化合物1是首次报道的含有C-8/C-11键和7,12-环氧部分的呋喃型异苦艾烷。通过广泛的光谱数据分析、电子圆二色性、Mo2(AcO)4诱导的圆二色性和单晶X射线衍射（Cu Kα）阐明了这些化合物的结构，包括绝对构型。化合物2、5和9在浓度为1.0 μM时对BV2细胞中脂多糖诱导的NO产生分别表现出10.2%、18.3%和16.1%的抑制作用，这与阳性对照姜黄素（1.0 μM时为12.9%）相当。
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