Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain.
Laboratorio de Neuroplasticidad y Neurodegeneración, Facultad de Medicina de Ciudad Real, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 13005 Ciudad Real, Spain.
Exp Neurol. 2016 Feb;276:13-21. doi: 10.1016/j.expneurol.2015.11.009. Epub 2015 Nov 23.
The principal olfactory structures display Alzheimer's disease (AD) related pathology at early stages of the disease. Consequently, olfactory deficits are among the earliest symptoms. Reliable olfactory tests for accurate clinical diagnosis are rarely made. In addition, neuropathological analysis postmortem of olfactory structures is often not made. Therefore, the relationship between the clinical features and the underlying pathology is poorly defined. Traditionally, research into Alzheimer's disease has focused on the degeneration of cortical temporal projection neurons and cholinergic neurons. Recent evidence has demonstrated the neurodegeneration of interneuron populations in AD. This review provides an updated overview of the pathological involvement of interneuron populations in the human olfactory system in Alzheimer's disease.
主要嗅觉结构在疾病早期就表现出与阿尔茨海默病（AD）相关的病理学变化。因此，嗅觉缺陷是最早出现的症状之一。很少有可靠的嗅觉测试可以进行准确的临床诊断。此外，通常也不会对嗅觉结构进行死后神经病理学分析。因此，临床特征与潜在病理学之间的关系尚未明确界定。传统上，对阿尔茨海默病的研究主要集中在皮质颞叶投射神经元和胆碱能神经元的退化上。最近的证据表明，AD 中存在中间神经元群体的神经退行性变。本综述提供了关于阿尔茨海默病中人类嗅觉系统中间神经元群体病理参与的最新概述。
