Singh Amarnath, Chandrasekharan Nair Kesavachandran, Kamal Ritul, Bihari Vipin, Gupta Manoj Kumar, Mudiam Mohana Krishna Reddy, Satyanarayana Gubbala Naga Venkata, Raj Abhay, Haq Izharul, Shukla Nishi Kumar, Khan Altaf Husain, Srivastava Anup Kumar
Epidemiology Division, CSIR-Indian Institute of Toxicology Research, Lucknow, India; Dept. of Biochemistry, Babu Banarasi Das University, BBD City, Faizabad Road, Lucknow, India.
Epidemiology Division, CSIR-Indian Institute of Toxicology Research, Lucknow, India.
Clin Chim Acta. 2016 Jan 15;452:204-13. doi: 10.1016/j.cca.2015.11.020. Epub 2015 Nov 23.
Indoor air pollution is associated with decreased pulmonary function but the relative impact of pollution from kitchen sources on health risks in kitchen workers is not well-known or studied. A study was conducted to measure the kitchen indoor air quality including PAHs estimation and risk assessment based on reported PAHs in indoor air in a central kitchen at North India.
A cross sectional study was undertaken to assess the lung function status using spirometer and urinary PAH metabolite measurements using GC-MS/MS among 94 male kitchen workers and their corresponding controls. Assessment of the indoor air quality levels was evaluated using standard methods.
All the indoor air pollutants were within the recommended guidelines except CO, TVOC and PAH emission in the kitchen. Incremental life time cancer risk (ICLR) based on indoor air PAH measurements indicates potential for carcinogenic risk. Significant lung function decline was observed among kitchen workers as compared to controls after adjusting for smoking habits. Urinary PAH metabolites were detected in kitchen workers and measured concentrations were comparatively higher than control subjects.
The decline in lung functions after adjustment for confounders and detection of urinary PAH metabolites in kitchen workers can be associated with higher concentrations of PAHs, CO and TVOCs in kitchen indoor air.
室内空气污染与肺功能下降有关，但厨房污染源产生的污染对厨房工作人员健康风险的相对影响尚不为人所知或研究较少。在印度北部的一个中央厨房进行了一项研究，以测量厨房室内空气质量，包括多环芳烃（PAHs）的评估以及基于室内空气中报告的PAHs进行风险评估。
进行了一项横断面研究，在94名男性厨房工作人员及其相应对照中，使用肺活量计评估肺功能状态，并使用气相色谱-串联质谱法（GC-MS/MS）测量尿中PAH代谢物。使用标准方法评估室内空气质量水平。
除了厨房中的一氧化碳（CO）、总挥发性有机化合物（TVOC）和PAH排放外，所有室内空气污染物均在推荐指南范围内。基于室内空气PAH测量的终生癌症风险增量（ICLR）表明存在致癌风险。在调整吸烟习惯后，与对照组相比，厨房工作人员的肺功能出现了显著下降。在厨房工作人员中检测到尿中PAH代谢物，且测量浓度相对高于对照组。
在调整混杂因素后厨房工作人员肺功能下降以及检测到尿中PAH代谢物，可能与厨房室内空气中较高浓度的PAHs、CO和TVOCs有关。
