Department of Environmental Health Engineering, School of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Fars Water and Wastewater Company, Shiraz, Iran.
Sci Rep. 2022 May 18;12(1):8254. doi: 10.1038/s41598-022-12040-8.
Polycyclic aromatic hydrocarbons (PAHs) are persistent toxic substances that have ubiquitous presence in water, air, soil, and sediment environments, posing serious environmental risks. The present study aimed to investigate the concentrations of urinary PAHs and their health effects in individuals living near restaurants via a health risk assessment analysis. This cross-sectional study was performed on 57 people living near restaurants and 30 individuals as the control group. Five urinary metabolites of PAHs were monitored. In order to evaluate the effects of the urinary metabolites of PAHs on Malondialdehyde (MDA) concentration, Total Anti-oxidation Capacity (TAC) in urine samples, and C-Reactive Protein (CRP) in serum samples, regression model was used by considering the effects of the possible confounding factors. Non-carcinogenic health risk was calculated, as well. The median concentration of urinary PAHs was 1196.70 and 627.54 ng/g creatinine in the people living near restaurants and the control group, respectively. Among the metabolites, the lowest and highest mean concentrations were related to 9-OHPhe and 1-OHP, respectively in the two study groups. Moreover, PAHs were significantly associated with MDA level and TAC (p < 0.05). Hazard Quotient (HQ) and Hazard Index (HI) were less than 1. Long-term studies are required to determine the actual health effects by identifying the sources of PAHs emission and to find ways to decrease the production of these compounds.
多环芳烃（PAHs）是持久性有毒物质，广泛存在于水、空气、土壤和沉积物环境中，对环境构成严重风险。本研究旨在通过健康风险评估分析，调查居住在餐馆附近人群尿液中 PAHs 的浓度及其健康影响。本横断面研究在 57 名居住在餐馆附近的人和 30 名作为对照组的个体中进行。监测了五种尿液中 PAHs 的代谢产物。为了评估 PAHs 尿液代谢产物对丙二醛（MDA）浓度、尿液中总抗氧化能力（TAC）和血清中 C-反应蛋白（CRP）的影响，考虑了可能的混杂因素的影响，使用回归模型进行了评估。还计算了非致癌健康风险。居住在餐馆附近人群和对照组尿液中 PAHs 的中位数浓度分别为 1196.70 和 627.54ng/g 肌酐。在代谢产物中，两组中最低和最高的平均浓度分别与 9-OHPhe 和 1-OHP 相关。此外，PAHs 与 MDA 水平和 TAC 显著相关（p<0.05）。危害商数（HQ）和危害指数（HI）均小于 1。需要进行长期研究，通过确定 PAHs 排放源来确定实际的健康影响，并寻找减少这些化合物产生的方法。
