Wang Hui, Lu Chang, Liu Xia, Zhang Wei
Department of Pathology, First Teaching Hospital of Xinjiang Medical University Xinjiang, China.
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11192-8. eCollection 2015.
Prognostic predictions in alveolar echinococcosis (AE) are usually based on relapse and metastasis. Thus, assessment of factors associated with metastasis and clinical outcomes in patients with alveolar echinococcosis are of significant important. The purpose of this study was to investigate the correlated factors for metastasis and prognosis for patients with AE.
We analyzed 159 AE patients who underwent curative surgery at the First Teaching Hospital of Xinjiang Medical University from February 2003 to December 2013 by hematoxylin and eosin (HE) staining. Immunohistochemistry (IHC) staining for CD44 was performed in 159 AE and adjacent normal liver specimens. The clinicopathological parameters were analyzed for metastasis and prognosis, including gender, age, size, calcification, necrosis, foreign body granuloma and CD44 protein level.
The rate of metastasis was 22.1%. Chi-square test showed that low levels of CD44 was associated with metastasis (P = 0.004). However, multivariate analysis suggested that CD44 expression is not independent prognostic indicators for overall survival (P = 0.356). In addition, no correlations between prognosis and gender, age, size, calcification, necrosis, foreign body granulomatous, metastasis were identified.
The finding that a low level of CD44 is associated with metastasis in AE patients. At present, it thus remains question whether CD44 expression is a valid prognostic marker for AE, further investigations are required.
泡型棘球蚴病（AE）的预后预测通常基于复发和转移情况。因此，评估泡型棘球蚴病患者中与转移及临床结局相关的因素具有重要意义。本研究旨在探讨AE患者转移及预后的相关因素。
我们分析了2003年2月至2013年12月在新疆医科大学第一附属医院接受根治性手术的159例AE患者，采用苏木精-伊红（HE）染色。对159例AE及相邻正常肝组织标本进行CD44免疫组织化学（IHC）染色。分析临床病理参数与转移及预后的关系，包括性别、年龄、大小、钙化、坏死、异物肉芽肿和CD44蛋白水平。
转移率为22.1%。卡方检验显示CD44低水平与转移相关（P = 0.004）。然而，多因素分析表明CD44表达不是总生存的独立预后指标（P = 0.356）。此外，未发现预后与性别、年龄、大小、钙化、坏死、异物肉芽肿、转移之间存在相关性。
发现AE患者中CD44低水平与转移相关。目前，CD44表达是否为AE的有效预后标志物仍存在疑问，需要进一步研究。
