Yes相关蛋白（YAP）在转移性乳腺癌中的表达。
Expression of Yes-associated protein (YAP) in metastatic breast cancer.
作者信息
Kim Hye Min, Jung Woo Hee, Koo Ja Seung
机构信息
Department of Pathology, Yonsei University College of Medicine Seoul, South Korea.
出版信息
Int J Clin Exp Pathol. 2015 Sep 1;8(9):11248-57. eCollection 2015.
The purpose of this study was to investigate the expression of Yes-associated protein (YAP) in different metastatic sites in metastatic breast cancer and to determine the clinical implications of these patterns. Immunohistochemical staining was used to investigate the expression of YAP and phospho-YAP in tissue microarrays from 122 cases of metastatic breast cancer (bone metastasis = 29, brain metastasis = 38, liver metastasis = 12, and lung metastasis = 43). The expression levels of YAP and phospho-YAP differed according to the metastatic site in metastatic breast cancer. Specifically, nuclear expression of phospho-YAP was high in brain metastasis but low in lung metastasis (P = 0.010). The effects of YAP and phospho-YAP expression on clinical outcomes were investigated by univariate analysis. This analysis showed that nuclear YAP positivity (P = 0.008) and nuclear phospho-YAP positivity (P = 0.003) were both associated with shorter overall survival. In conclusion, the level of YAP expression varies according to the metastatic site in metastatic breast cancer. Moreover, high YAP expression was correlated with poor prognosis.
本研究的目的是调查Yes相关蛋白（YAP）在转移性乳腺癌不同转移部位的表达情况，并确定这些表达模式的临床意义。采用免疫组织化学染色法，对122例转移性乳腺癌（骨转移29例、脑转移38例、肝转移12例、肺转移43例）组织芯片中YAP和磷酸化YAP的表达进行研究。转移性乳腺癌中YAP和磷酸化YAP的表达水平因转移部位而异。具体而言，磷酸化YAP的核表达在脑转移中较高，而在肺转移中较低（P = 0.010）。通过单因素分析研究YAP和磷酸化YAP表达对临床结局的影响。该分析表明，核YAP阳性（P = 0.008）和核磷酸化YAP阳性（P = 0.003）均与较短的总生存期相关。总之，转移性乳腺癌中YAP的表达水平因转移部位而异。此外，YAP高表达与预后不良相关。
Zotero 插件