Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O.Box: 19395-4763, Tehran, Iran.
Maragheh University of Medical Sciences, Maragheh, Iran.
BMC Res Notes. 2023 Sep 11;16(1):204. doi: 10.1186/s13104-023-06463-3.
This study aimed to investigate the interaction of the healthy eating index (HEI) and the dietary approach to stop hypertension (DASH) diet scores with FTO polymorphisms in relation to change in obesity traits. A total of 4480 subjects aged ≥ 18 years were selected from participants of the Tehran lipid and glucose study and followed-up 3 years. Selected polymorphisms (rs1421085, rs1121980, rs8050136) were genotyped and genetic risk score (GRS) was computed. HEI and DASH scores were computed based on dietary data. Changes in body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR) and visceral adiposity index (VAI) were measured. Higher adherence to both DASH and HEI scores were increased with higher ages. Individuals with high GRS had a lower change in BMI when they had higher adherence to HEI, compared to subjects with lower HEI score (P trend = 0.01). Change in WC in participants in the fourth quartile of HEI score in minor allele carriers of FTO variants was lower compared to the first quartile; conversely, higher adherence to the DASH score by this genotypic group was related to increase in WC. No significant interaction was seen between FTO polymorphisms and both diet scores regarding changes in any of obesity traits. In conclusion, in individuals with high GRS higher adherence to HEI score was associated with lower change in BMI and WC, while higher adherence to DASH diet was associated with higher change in WC, compared to individuals with lower adherence to both scores.
本研究旨在探讨健康饮食指数（HEI）和停止高血压的饮食方法（DASH）饮食评分与 FTO 多态性之间的相互作用，以及它们与肥胖特征变化的关系。本研究共选择了 4480 名年龄≥18 岁的受试者，这些受试者均来自德黑兰血脂和血糖研究的参与者，并进行了 3 年的随访。选择了三个特定的多态性（rs1421085、rs1121980、rs8050136）进行基因分型，并计算了遗传风险评分（GRS）。根据饮食数据计算了 HEI 和 DASH 评分。测量了体重指数（BMI）、腰围（WC）、腰臀比（WHR）和内脏脂肪指数（VAI）的变化。DASH 和 HEI 评分的依从性越高，年龄越大。与 HEI 评分较低的受试者相比，GRS 较高的个体，当 HEI 评分较高时，BMI 的变化较小（P 趋势=0.01）。在 FTO 变异体的杂合子携带者中，HEI 评分第四四分位数的个体，其 WC 的变化低于第一四分位数；相反，该基因型组对 DASH 评分的较高依从性与 WC 的增加有关。FTO 多态性与两种饮食评分之间，在任何肥胖特征的变化方面均未观察到显著的交互作用。总之，在 GRS 较高的个体中，较高的 HEI 评分依从性与 BMI 和 WC 的变化较小有关，而较高的 DASH 饮食依从性与 WC 的变化较大有关，与两个评分依从性较低的个体相比。
