白细胞介素-18拮抗剂改善了小鼠疟疾感染的组织病理学状况。
Interleukin-18 Antagonism Improved Histopathological Conditions of Malaria Infection in Mice.
作者信息
Jabbarzare Marzieh, Chin Voon Kin, Talib Herni, Yam Mun Fei, Adam Siti Khadijah, Hassan Haniza, Abdul Majid Roslaini, Mat Taib Che Norma, Mohd Moklas Mohamad Aris, Taufik Hidayat Mohamad, Mohd Sidek Hasidah, Basir Rusliza
机构信息
Dept. of Human Anatomy, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
Dept. of Biomedical Sciences, Faculty of Medicine & Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia.
出版信息
Iran J Parasitol. 2015 Jul-Sep;10(3):389-401.
BACKGROUND
Interleukin 18 (IL-18) exerts pleiotropic roles in many inflammatory-related diseases including parasitic infection. Previous studies have demonstrated the promising therapeutic potential of modulating IL-18 bioactivity in various pathological conditions. However, its involvement during malaria infection has yet to be established. In this study, we demonstrated the effect of modulating IL-18 on the histopathological conditions of malaria infected mice.
METHODS
Plasmodium berghei ANKA infection in male ICR mice was used as a model for malaria infection. Modulation of IL-18 release was carried out by treatment of malarial mice with recombinant mouse IL-18 (rmIL-18) and recombinant mouse IL-18 Fc chimera (rmIL-18Fc) intravenously. Histopathological study and analysis were performed on major organs including brain, liver, spleen, lungs and kidney.
RESULTS
Treatment with rmIL-18Fc resulted in significant improvements on the histopathological conditions of the organs in malaria-infected mice.
CONCLUSION
IL-18 is an important mediator of malaria pathogenesis and targeting IL-18 could prove beneficial in malaria-infected host.
背景
白细胞介素18（IL-18）在包括寄生虫感染在内的许多炎症相关疾病中发挥多效性作用。先前的研究已证明在各种病理条件下调节IL-18生物活性具有潜在的治疗潜力。然而，其在疟疾感染过程中的作用尚未明确。在本研究中，我们证明了调节IL-18对疟疾感染小鼠组织病理学状况的影响。
方法
以雄性ICR小鼠感染伯氏疟原虫ANKA作为疟疾感染模型。通过静脉注射重组小鼠IL-18（rmIL-18）和重组小鼠IL-18 Fc嵌合体（rmIL-18Fc）来调节疟疾小鼠IL-18的释放。对包括脑、肝、脾、肺和肾在内的主要器官进行组织病理学研究和分析。
结果
用rmIL-18Fc治疗可显著改善疟疾感染小鼠器官的组织病理学状况。
结论
IL-18是疟疾发病机制的重要介质，靶向IL-18可能对疟疾感染宿主有益。
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