Wang Arthur, Kleinman George, Murali Raj, Wainwright John, Tandon Adesh
Department of Neurosurgery, New York Medical College, Westchester, Valhalla, New York, United States.
Department of Pathology, New York Medical College, Westchester, Valhalla, New York, United States.
J Neurol Surg Rep. 2015 Nov;76(2):e282-6. doi: 10.1055/s-0035-1566125. Epub 2015 Oct 29.
We present an unusual case of a metastatic renal cell carcinoma (RCC) mimicking trigeminal schwannoma. The patient, with no prior history of RCC, presented with clinical symptoms and imaging consistent with trigeminal neuralgia secondary to trigeminal schwannoma. Magnetic resonance imaging of the brain showed a large bilobed cystic/solid mass primarily in the cerebellopontine angle cistern, with extension into the left middle cranial fossa, Meckel cave, and left cavernous sinus. Following surgical excision, histopathology revealed the tumor to be an RCC infiltrating into the trigeminal nerve fascicles. Further imaging and investigation revealed widespread metastasis to the vertebral bodies and long bones. Metastatic RCC to the trigeminal nerve is rare. Despite the development of more effective treatment modalities, the prognosis of metastatic RCC remains poor. To our knowledge, this is the first reported case of RCC metastasizing to the trigeminal nerve fascicles.
我们报告了一例罕见的转移性肾细胞癌（RCC），其表现酷似三叉神经鞘瘤。该患者既往无RCC病史，临床表现及影像学检查结果均符合继发于三叉神经鞘瘤的三叉神经痛。脑部磁共振成像显示，一个主要位于桥小脑角池的大的双叶囊性/实性肿块，延伸至左侧中颅窝、Meckel腔和左侧海绵窦。手术切除后，组织病理学检查显示肿瘤为浸润三叉神经束的RCC。进一步的影像学检查和调查发现椎体和长骨广泛转移。RCC转移至三叉神经罕见。尽管出现了更有效的治疗方式，但转移性RCC的预后仍然很差。据我们所知，这是首例报道的RCC转移至三叉神经束的病例。
